Lehualides E-K，来自汤加海洋海绵 Plakortis sp. 的细胞毒性代谢产物

Lehualides E-K, cytotoxic metabolites from the Tongan marine sponge Plakortis sp.

机构信息

Centre for Biodiscovery and School of Chemical and Physical Sciences, Victoria University of Wellington, PO Box 600, Wellington, New Zealand.

出版信息

J Nat Prod. 2011 Apr 25;74(4):809-15. doi: 10.1021/np100868t. Epub 2011 Feb 25.

DOI:10.1021/np100868t

PMID:21351759

Abstract

Spectroscopy-guided chemical analysis of a marine sponge from the genus Plakortis, collected in Tonga, yielded seven new metabolites of polyketide origin, lehualides E-K (5-11), four of which incorporate various sulfur functionalities. The structures of compounds 5-11 were elucidated by interpretation of spectroscopic data and spectral comparison with model compounds. The biological activities of compounds 6-9 were investigated against human promyeloid leukemic HL-60 cells and two yeast strains, wild-type and a drug-sensitive mutant.

摘要

对在汤加采集的属于 Plakortis 属的一种海绵进行光谱指导下的化学分析，得到了七个新的聚酮类化合物代谢物 lehualides E-K（5-11），其中有四个化合物含有不同的硫官能团。通过对光谱数据的解释和与模型化合物的光谱比较，确定了化合物 5-11 的结构。对化合物 6-9 的生物活性进行了研究，测试了它们对人类早幼粒细胞白血病 HL-60 细胞和两种酵母菌株（野生型和一种药物敏感突变株）的抑制作用。