Kossuga Miriam H, Nascimento Andréa M, Reimão Juliana Q, Tempone André G, Taniwaki Noemi Nosomi, Veloso Katyuscya, Ferreira Antonio G, Cavalcanti Bruno C, Pessoa Claudia, Moraes Manoel O, Mayer Alejandro M S, Hajdu Eduardo, Berlinck Roberto G S
Instituto de quimica de Sao Carlos, Universidade de Sao Paulo, Sao Carlos, Brazil.
J Nat Prod. 2008 Mar;71(3):334-9. doi: 10.1021/np0705256. Epub 2008 Jan 5.
Investigation of the bioactive crude extract from the sponge Plakortis angulospiculatus from Brazil led to the isolation of plakortenone ( 1) as a new polyketide, along with five known polyketides ( 2- 6) previously isolated from other Plakortis sponges. The known polyketides were tested in antileishmanial, antitrypanosomal, antineuroinflammatory, and cytotoxicity assays. The results show that plakortide P ( 3) is a potent antiparasitic compound, against both Leishmania chagasi and Trypanosona cruzi, and exhibited antineuroinflammatory activity. The known polyketides 2- 6 were tested for cytotoxicity against four human cancer cell lines, but displayed only moderate cytotoxic activity.
对来自巴西的海绵状角刺扁海绵（Plakortis angulospiculatus）的生物活性粗提物进行研究，从中分离出了一种新的聚酮化合物——扁海绵烯酮（1），以及五种先前从其他扁海绵属海绵中分离出的已知聚酮化合物（2 - 6）。对这些已知聚酮化合物进行了抗利什曼原虫、抗锥虫、抗神经炎症和细胞毒性测定。结果表明，扁海绵肽P（3）是一种有效的抗寄生虫化合物，对恰加斯利什曼原虫和克氏锥虫均有作用，并且具有抗神经炎症活性。对已知聚酮化合物2 - 6针对四种人类癌细胞系进行了细胞毒性测试，但仅表现出中等程度的细胞毒性活性。
