Kondo C, Caputo G R, Masui T, Foster E, O'Sullivan M, Stulbarg M S, Golden J, Catterjee K, Higgins C B
Department of Radiology, University of California, San Francisco 94143.
Radiology. 1992 Jun;183(3):751-8. doi: 10.1148/radiology.183.3.1584932.
Velocity-encoded cine magnetic resonance (MR) imaging provides two-dimensional velocity maps of a cross-sectional area of a vessel. Pulmonary flow and flow patterns in the main pulmonary artery were analyzed with velocity-encoded cine MR imaging and Doppler echocardiography in 10 patients with pulmonary hypertension (PH), one patient with a dilated main pulmonary artery, and 10 healthy subjects, and these findings were compared. Peak systolic velocity measured with velocity-encoded cine MR imaging was similar to that measured with Doppler echocardiography in healthy subjects and in patients with PH. Velocity-encoded cine MR imaging demonstrated substantial differences in velocity across the vascular lumen in PH. The flow pattern in healthy subjects was different than that in patients with PH; the latter had lower peak systolic velocity and greater retrograde flow after middle to late systole. The retrograde flow observed in patients with PH reflected hemodynamic events, since it was inversely proportional to pulmonary flow volume and directly proportional to pulmonary resistance and cross-sectional area of the vessel. Velocity-encoded cine MR imaging demonstrates an inhomogeneous flow profile in PH and may serve as a noninvasive method to estimate pulmonary vascular resistance.
速度编码电影磁共振（MR）成像可提供血管横截面区域的二维速度图。对10例肺动脉高压（PH）患者、1例主肺动脉扩张患者和10名健康受试者，采用速度编码电影MR成像和多普勒超声心动图分析肺血流及主肺动脉内的血流模式，并对这些结果进行比较。在健康受试者和PH患者中，用速度编码电影MR成像测得的收缩期峰值速度与用多普勒超声心动图测得的相似。速度编码电影MR成像显示PH患者血管腔内速度存在显著差异。健康受试者的血流模式与PH患者不同；后者收缩期峰值速度较低，收缩中期至晚期后逆向血流较多。在PH患者中观察到的逆向血流反映了血流动力学事件，因为它与肺血流量成反比，与肺阻力和血管横截面积成正比。速度编码电影MR成像显示PH患者血流分布不均匀，可作为估计肺血管阻力的无创方法。
