Baker C, Pradhan A, Pakstis L, Pochan Darrin J, Shah S Ismat
Department of Materials Science and Engineering, University of Delaware, Newark, Deleware 19716, USA.
J Nanosci Nanotechnol. 2005 Feb;5(2):244-9. doi: 10.1166/jnn.2005.034.
Nanometer sized silver particles were synthesized by inert gas condensation and co-condensation techniques. Both techniques are based on the evaporation of a metal into an inert atmosphere with the subsequent cooling for the nucleation and growth of the nanoparticles. The antibacterial efficiency of the nanoparticles was investigated by introducing the particles into a media containing Escherichia coli. The antibacterial investigations were performed in solution and on petri dishes. The silver nanoparticles were found to exhibit antibacterial effects at low concentrations. The antibacterial properties were related to the total surface area of the nanoparticles. Smaller particles with a larger surface to volume ratio provided a more efficient means for antibacterial activity. The nanoparticles were found to be completely cytotoxic to E. coli for surface concentrations as low as 8 microg of Ag/cm2.
通过惰性气体冷凝和共冷凝技术合成了纳米级银颗粒。这两种技术都基于将金属蒸发到惰性气氛中，随后冷却以使纳米颗粒成核和生长。通过将颗粒引入含有大肠杆菌的培养基中来研究纳米颗粒的抗菌效率。抗菌研究在溶液中和培养皿上进行。发现银纳米颗粒在低浓度下具有抗菌作用。抗菌性能与纳米颗粒的总表面积有关。具有较大表面积与体积比的较小颗粒提供了更有效的抗菌活性手段。发现对于低至8微克银/平方厘米的表面浓度，纳米颗粒对大肠杆菌具有完全的细胞毒性。
