Mayr Ulrike Beate, Walcher Petra, Azimpour Chakameh, Riedmann Eva, Haller Christoph, Lubitz Werner
Department of Medical/Pharmaceutical Chemistry, University of Vienna, A-1090 Vienna, Austria.
Adv Drug Deliv Rev. 2005 Jun 17;57(9):1381-91. doi: 10.1016/j.addr.2005.01.027. Epub 2005 Apr 20.
The bacterial ghost system is a novel vaccine delivery system unusual in that it combines excellent natural intrinsic adjuvant properties with versatile carrier functions for foreign antigens. The efficient tropism of bacterial ghosts (BG) for antigen presenting cells promotes the generation of both cellular and humoral responses to heterologous antigens and carrier envelope structures. The simplicity of both BG production and packaging of (multiple) target antigens makes them particularly suitable for use as combination vaccines. Further advantages of BG vaccines include a long shelf-life without the need of cold-chain storage due to their freeze-dried status, they are safe as they do not involve host DNA or live organisms, they exhibit improved potency with regard to target antigens compared to conventional approaches, they are versatile with regards to DNA or protein antigen choice and size, and as a delivery system they offer high bioavailability.
细菌幽灵系统是一种新型疫苗递送系统，其独特之处在于它将出色的天然固有佐剂特性与对外源抗原的多功能载体功能相结合。细菌幽灵（BG）对抗抗原呈递细胞的高效趋向性促进了对异源抗原和载体包膜结构产生细胞免疫和体液免疫反应。BG生产的简便性以及（多种）靶抗原的包装使其特别适合用作联合疫苗。BG疫苗的其他优点包括：由于其冻干状态，无需冷链储存，保质期长；它们是安全的，因为不涉及宿主DNA或活生物体；与传统方法相比，它们在靶抗原方面表现出更高的效力；在DNA或蛋白质抗原的选择和大小方面具有通用性；作为一种递送系统，它们具有高生物利用度。
