评估用于检测疫苗接种者麻疹免疫力的口腔液中特异性免疫球蛋白G的商业检测方法。
Evaluation of commercial assay detecting specific immunoglobulin g in oral fluid for determining measles immunity in vaccinees.
作者信息
Kremer Jacques R, Muller Claude P
机构信息
Institute of Immunology, WHO Collaborative Centre for Measles, WHO European Regional Reference Laboratory for Measles and Rubella, Laboratoire National de Santé, L-1011 Luxembourg.
出版信息
Clin Diagn Lab Immunol. 2005 May;12(5):668-70. doi: 10.1128/CDLI.12.5.668-670.2005.
Abstract
A commercial assay for detection of measles immunoglobulin G (IgG) in oral fluid was evaluated in a highly vaccinated cohort using serum IgG as gold standard. In contrast to previous studies from cohorts protected by natural immunity, antibody prevalence was significantly underestimated (-7.4%; confidence interval: -1.5 to -13.2%; P = 0.01) due to a reduced sensitivity when antibody levels were low.
摘要
在一个高疫苗接种率队列中，以血清IgG作为金标准，对一种用于检测口腔液中麻疹免疫球蛋白G（IgG）的商业检测方法进行了评估。与之前来自受自然免疫保护队列的研究不同，由于抗体水平较低时灵敏度降低，抗体流行率被显著低估（-7.4%；置信区间：-1.5至-13.2%；P = 0.01）。
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