眶额皮质中的乙酰胆碱对于习得社会传递性食物偏好是必需的。
Acetylcholine in the orbitofrontal cortex is necessary for the acquisition of a socially transmitted food preference.
作者信息
Ross Robert S, McGaughy Jill, Eichenbaum Howard
机构信息
Center for Memory and Brain, Psychology Department, Boston University, Boston, Massachusetts, 02215, USA.
出版信息
Learn Mem. 2005 May-Jun;12(3):302-6. doi: 10.1101/lm.91605. Epub 2005 May 16.
Abstract
The social transmission of food preference task (STFP) has been used to examine the involvement of the hippocampus in learning and memory for a natural odor-odor association. However, cortical involvement in STFP has not been extensively studied. The orbitofrontal cortex (OFC) is important in odor-guided learning, and cholinergic depletion of the entire neocortex results in impairments in STFP. Here we examined the specific role of cholinergic modulation in the OFC by assessing the effect of 192 immunoglobulin G-saporin infusion directly into OFC prior to training on STFP. Cholinergic depletion in the OFC impaired expression of the socially transmitted odor association measured 2 d after training, indicating that cholinergic function in the OFC is essential for this form of associative learning.
摘要
食物偏好任务的社会传递（STFP）已被用于研究海马体在自然气味-气味关联学习和记忆中的作用。然而，皮质在STFP中的作用尚未得到广泛研究。眶额皮质（OFC）在气味引导学习中很重要，整个新皮质的胆碱能耗竭会导致STFP受损。在这里，我们通过评估在训练STFP之前直接向OFC注入192免疫球蛋白G-皂草素的效果，来研究胆碱能调制在OFC中的特定作用。训练后2天测量，OFC中的胆碱能耗竭损害了社会传递气味关联的表达，表明OFC中的胆碱能功能对于这种形式的联想学习至关重要。
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