Alvarez P, Lipton P A, Melrose R, Eichenbaum H
Laboratory for Cognitive Neurobiology, Department of Psychology, Boston University, Boston, Massachusetts 02215, USA.
Learn Mem. 2001 Mar-Apr;8(2):79-86. doi: 10.1101/lm.38201.
Debate continues on whether the role of rodent hippocampus in memory is limited to the spatial domain. Recently, this controversy has been addressed with studies on the social transmission of food preference, an odor-odor association task with no spatial requirements. Multiple reports have concluded that damage to the hippocampal region impairs memory in this task, but there remain questions about the extent of damage essential to produce an impairment. Furthermore, a recent study () found no effect of hippocampal lesions on memory in this task. We tested animals with complete lesions of the hippocampus (H) lesions of the hippocampus plus subiculum (HS), and lesions of the adjacent, anatomically related cortices of the parahippocampal region (PHR). H lesions produced an impairment on spatial delayed alternation, but not on memory for the social transmission of food preference, whereas HS and PHR lesions produced severe and equivalent impairments on memory for the socially acquired food preference. We discuss possible explanations for the discrepancy with the results of and conclude that the hippocampus and subiculum together play a critical role in the formation of this form of nonspatial, relational memory.
关于啮齿动物海马体在记忆中的作用是否仅限于空间领域，仍存在争议。最近，通过对食物偏好的社会传递研究（一种无空间要求的气味 - 气味关联任务）解决了这一争议。多项报告得出结论，海马体区域受损会损害该任务中的记忆，但对于产生损害所需的损伤程度仍存在疑问。此外，最近一项研究（）发现海马体损伤对该任务中的记忆没有影响。我们测试了海马体完全损伤（H）、海马体加下托损伤（HS）以及海马旁区域相邻的、解剖学相关皮质损伤（PHR）的动物。H损伤对空间延迟交替产生了损害，但对食物偏好社会传递的记忆没有影响，而HS和PHR损伤对通过社会习得的食物偏好的记忆产生了严重且相当的损害。我们讨论了与结果存在差异的可能解释，并得出结论，海马体和下托共同在这种非空间关系记忆的形成中起关键作用。
