Pacini Franco, Calabrese Carlo, Cipolletta Livio, Valva Mario D'Ayala, Russo Antonio, Savarino Vincenzo, Vigneri Sergio
Azienda Ospedaliera Careggi UO di Gastroenterologia, Florence, Italy.
Curr Med Res Opin. 2005 Apr;21(4):495-502. doi: 10.1185/030079905X38231.
Gastro-oesophageal reflux disease (GORD), characterized by frequent episodes of heartburn, imposes considerable burdens on both patients and health services. In addition to both patients and health services. In addition to gastrointestinal symptoms, GORD may precipitate a variety of extra-oesophageal complications, such as asthma and chest pain, which can significantly impair patients' quality of life. This paper aims to describe the impact of heartburn on patients' health-related quality of life (HRQL) in Italy.
Consecutive patients from general practices and gastroenterology clinics who were experiencing heartburn were invited to complete a selection of standardized patient-reported outcomes instruments, including Italian translations of the Gastrointestinal Symptom Rating Scale (GSRS), Short-Form 36 (SF-36), Quality of Life in Reflux and Dyspepsia questionnaire (QOLRAD) and Hospital Anxiety and Depression (HAD) scale. Frequency and severity of heartburn in the preceding week were recorded.
Assessments were completed by 152 patients (mean age, 47 years), of whom 60% were female. Sixty-one per cent had moderate symptoms and 74% had symptoms on three or more days in the previous week. Patients were most bothered by reflux, abdominal pain and indigestion. As a result of their symptoms, patients experienced impaired vitality, sleep disturbance and other alimentary problems. This led to impaired HRQL across all but one SF-36 domain. According to the HAD scale, 21% of patients were depressed and 19% were anxious.
GORD substantially impairs many aspects of HRQL, including sleep, vitality and emotional health.
胃食管反流病（GORD）以频繁烧心发作为特征，给患者和医疗服务带来了相当大的负担。除了患者和医疗服务外，GORD除胃肠道症状外，还可能引发多种食管外并发症，如哮喘和胸痛，这会显著损害患者的生活质量。本文旨在描述烧心对意大利患者健康相关生活质量（HRQL）的影响。
邀请来自全科诊所和胃肠病科诊所的连续出现烧心症状的患者完成一系列标准化的患者报告结局量表，包括意大利语翻译版的胃肠道症状评分量表（GSRS）、简明健康调查问卷（SF-36）、反流和消化不良生活质量问卷（QOLRAD）以及医院焦虑抑郁量表（HAD）。记录前一周烧心的频率和严重程度。
152名患者（平均年龄47岁）完成了评估，其中60%为女性。61%有中度症状，74%在前一周有三天或更多天出现症状。患者最困扰的是反流、腹痛和消化不良。由于这些症状患者的活力受损、睡眠受到干扰并出现其他消化问题。这导致除一个SF-36领域外，所有领域的HRQL均受损。根据HAD量表，21%的患者有抑郁情绪，19%的患者有焦虑情绪。结论：GORD严重损害了HRQL的多个方面，包括睡眠、活力和情绪健康。
