从兔子中分离并鉴定一种新型杯状病毒。

Isolation and characterization of a new Vesivirus from rabbits.

作者信息

Martín-Alonso José M, Skilling Douglas E, González-Molleda Lorenzo, del Barrio Gloria, Machín Angeles, Keefer Nathan K, Matson David O, Iversen Patrick L, Smith Alvin W, Parra Francisco

机构信息

Departamento de Bioquímica y Biología Molecular, Instituto Universitario de Biotecnología de Asturias, Edificio Santiago Gascón, Campus El Cristo, Universidad de Oviedo, 33006 Oviedo, Spain.

出版信息

Virology. 2005 Jul 5;337(2):373-83. doi: 10.1016/j.virol.2005.04.018.

DOI:10.1016/j.virol.2005.04.018

PMID:15901487

Abstract

This report describes the isolation, cDNA cloning, complete genome nucleotide sequence, and partial characterization of a new cultivable calicivirus isolated from juvenile feeder European rabbits (Oryctolagus cuniculus) showing symptoms of diarrhea. Absence of neutralization by type-specific neutralizing antibodies for 40 caliciviruses and phylogenetic sequence comparisons of the open reading frame 1-encoded polyprotein with those of other caliciviruses demonstrate that this new calicivirus is a putative novel member of the Vesivirus genus which is closely related to the marine calicivirus subgroup. According to its putative classification, this new virus has been named rabbit vesivirus.

摘要

本报告描述了从出现腹泻症状的幼龄欧洲肉兔（穴兔）中分离出的一种新的可培养杯状病毒，包括其cDNA克隆、全基因组核苷酸序列及部分特性。针对40种杯状病毒的型特异性中和抗体无法中和该病毒，且对开放阅读框1编码的多聚蛋白与其他杯状病毒进行系统发育序列比较后表明，这种新的杯状病毒是杯状病毒属的一个推定新成员，与海洋杯状病毒亚组密切相关。根据其推定分类，这种新病毒被命名为兔杯状病毒。