Martín-Alonso José M, Skilling Douglas E, González-Molleda Lorenzo, del Barrio Gloria, Machín Angeles, Keefer Nathan K, Matson David O, Iversen Patrick L, Smith Alvin W, Parra Francisco
Departamento de Bioquímica y Biología Molecular, Instituto Universitario de Biotecnología de Asturias, Edificio Santiago Gascón, Campus El Cristo, Universidad de Oviedo, 33006 Oviedo, Spain.
Virology. 2005 Jul 5;337(2):373-83. doi: 10.1016/j.virol.2005.04.018.
This report describes the isolation, cDNA cloning, complete genome nucleotide sequence, and partial characterization of a new cultivable calicivirus isolated from juvenile feeder European rabbits (Oryctolagus cuniculus) showing symptoms of diarrhea. Absence of neutralization by type-specific neutralizing antibodies for 40 caliciviruses and phylogenetic sequence comparisons of the open reading frame 1-encoded polyprotein with those of other caliciviruses demonstrate that this new calicivirus is a putative novel member of the Vesivirus genus which is closely related to the marine calicivirus subgroup. According to its putative classification, this new virus has been named rabbit vesivirus.
本报告描述了从出现腹泻症状的幼龄欧洲肉兔（穴兔）中分离出的一种新的可培养杯状病毒，包括其cDNA克隆、全基因组核苷酸序列及部分特性。针对40种杯状病毒的型特异性中和抗体无法中和该病毒，且对开放阅读框1编码的多聚蛋白与其他杯状病毒进行系统发育序列比较后表明，这种新的杯状病毒是杯状病毒属的一个推定新成员，与海洋杯状病毒亚组密切相关。根据其推定分类，这种新病毒被命名为兔杯状病毒。
