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本文引用的文献

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Structure of the periplasmic component of a bacterial drug efflux pump.细菌药物外排泵周质组分的结构
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RamA is an alternate activator of the multidrug resistance cascade in Enterobacter aerogenes.RamA是产气肠杆菌中多药耐药级联反应的一种替代激活剂。
Antimicrob Agents Chemother. 2004 Jul;48(7):2518-23. doi: 10.1128/AAC.48.7.2518-2523.2004.
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Role of histone-like protein H-NS in multidrug resistance of Escherichia coli.组蛋白样蛋白H-NS在大肠杆菌多重耐药性中的作用
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Bile salts and fatty acids induce the expression of Escherichia coli AcrAB multidrug efflux pump through their interaction with Rob regulatory protein.胆汁盐和脂肪酸通过与Rob调节蛋白相互作用诱导大肠杆菌AcrAB多药外排泵的表达。
Mol Microbiol. 2003 Jun;48(6):1609-19. doi: 10.1046/j.1365-2958.2003.03531.x.
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An extended role for the nucleoid structuring protein H-NS in the virulence gene regulatory cascade of Shigella flexneri.类核结构蛋白H-NS在福氏志贺氏菌毒力基因调控级联反应中的扩展作用。
Mol Microbiol. 2003 Feb;47(3):825-38. doi: 10.1046/j.1365-2958.2003.03347.x.
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Crystal structure of bacterial multidrug efflux transporter AcrB.细菌多药外排转运蛋白AcrB的晶体结构
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The AcrAB-TolC efflux pump contributes to multidrug resistance in the nosocomial pathogen Enterobacter aerogenes.AcrAB-TolC外排泵导致医院病原体产气肠杆菌产生多重耐药性。
Antimicrob Agents Chemother. 2002 Aug;46(8):2640-3. doi: 10.1128/AAC.46.8.2640-2643.2002.
8
mar Operon involved in multidrug resistance of Enterobacter aerogenes.mar操纵子与产气肠杆菌的多药耐药性有关。
Antimicrob Agents Chemother. 2002 Apr;46(4):1093-7. doi: 10.1128/AAC.46.4.1093-1097.2002.
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Large-scale monitoring of pleiotropic regulation of gene expression by the prokaryotic nucleoid-associated protein, H-NS.对原核生物类核相关蛋白H-NS对基因表达的多效性调控进行大规模监测。
Mol Microbiol. 2001 Apr;40(1):20-36. doi: 10.1046/j.1365-2958.2001.02358.x.
10
National epidemiologic surveys of Enterobacter aerogenes in Belgian hospitals from 1996 to 1998.1996年至1998年比利时医院产气肠杆菌的全国性流行病学调查。
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在产气肠杆菌中，eefABC多药外排泵操纵子受H-NS抑制。

The eefABC multidrug efflux pump operon is repressed by H-NS in Enterobacter aerogenes.

作者信息

Masi Muriel, Pagès Jean-Marie, Villard Claude, Pradel Elizabeth

机构信息

Enveloppe bactérienne, Perméabilité et Antibiotiques, EA2197, Faculté de Médecine, Marseille, France.

出版信息

J Bacteriol. 2005 Jun;187(11):3894-7. doi: 10.1128/JB.187.11.3894-3897.2005.

DOI:10.1128/JB.187.11.3894-3897.2005
PMID:15901719
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1112065/
Abstract

The Enterobacter aerogenes eefABC locus, which encodes a tripartite efflux pump, was cloned by complementation of an Escherichia coli tolC mutant. E. aerogenes deltaacrA expressing EefABC became less susceptible to a wide range of antibiotics. Data from eef::lacZ fusions showed that eefABC was not transcribed in the various laboratory conditions tested. However, increased transcription from Peef was observed in an E. coli hns mutant. In addition, EefA was detected in E. aerogenes expressing a dominant negative E. coli hns allele.

摘要

产气肠杆菌的eefABC基因座编码一种三联外排泵，通过对大肠杆菌tolC突变体进行互补克隆得到该基因座。表达EefABC的产气肠杆菌ΔacrA对多种抗生素的敏感性降低。来自eef::lacZ融合的数据表明，在测试的各种实验室条件下，eefABC均未转录。然而，在大肠杆菌hns突变体中观察到来自Peef的转录增加。此外，在表达显性负性大肠杆菌hns等位基因的产气肠杆菌中检测到EefA。