Crompton K E, Prankerd R J, Paganin D M, Scott T F, Horne M K, Finkelstein D I, Gross K A, Forsythe J S
School of Physics and Materials Engineering, Monash University, Wellington Rd, Clayton, VIC 3800, Australia.
Biophys Chem. 2005 Aug 22;117(1):47-53. doi: 10.1016/j.bpc.2005.03.009.
The morphology of physical hydrogels is often difficult to examine due to the delicate nature of the system and therefore has not been studied in detail. Chitosan/GP (glycerophosphate salt) is a significant hydrogel in the biomedical and cosmetic fields as it is thermosensitive and contains less than 5% polysaccharide. The morphology of this system was examined with laser scanning confocal microscopy (LSCM) to image the gel morphology. The images indicate that the gel is quite heterogeneous, and power spectra reveal a fractal-like morphology. A study of composition found that increasing chitosan concentration increased the amount of polymer-rich phase present in the gel, and that the smallest aggregates decreased in size.
由于物理水凝胶体系性质脆弱，其形态通常难以检测，因此尚未得到详细研究。壳聚糖/甘油磷酸盐是生物医学和化妆品领域一种重要的水凝胶，因为它具有热敏性且多糖含量低于5%。用激光扫描共聚焦显微镜（LSCM）对该体系的形态进行检测，以成像凝胶形态。图像表明凝胶相当不均匀，功率谱显示出类似分形的形态。一项成分研究发现，壳聚糖浓度的增加会使凝胶中富含聚合物的相的量增加，且最小聚集体的尺寸减小。
