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基于壳聚糖的水凝胶在皮肤感染管理中的应用综述

Chitosan-Based Hydrogel in the Management of Dermal Infections: A Review.

作者信息

Mohite Popat, Rahayu Pudji, Munde Shubham, Ade Nitin, Chidrawar Vijay R, Singh Sudarshan, Jayeoye Titilope J, Prajapati Bhupendra G, Bhattacharya Sankha, Patel Ravish J

机构信息

Department of Pharmaceutical Quality Assurance, A.E.T.'s St. John Institute of Pharmacy and Research, Palghar 401404, Maharashtra, India.

Department of Pharmacy of Tanjung Karang State Health Polytechnic, Soekarno-Hatta, Bandar Lampung 35145, Lampung, Indonesia.

出版信息

Gels. 2023 Jul 24;9(7):594. doi: 10.3390/gels9070594.

DOI:10.3390/gels9070594
PMID:37504473
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10379151/
Abstract

The main objective of this review is to provide a comprehensive overview of the current evidence regarding the use of chitosan-based hydrogels to manage skin infections. Chitosan, a naturally occurring polysaccharide derived from chitin, possesses inherent antimicrobial properties, making it a promising candidate for treating various dermal infections. This review follows a systematic approach to analyze relevant studies that have investigated the effectiveness of chitosan-based hydrogels in the context of dermal infections. By examining the available evidence, this review aims to evaluate these hydrogels' overall efficacy, safety, and potential applications for managing dermal infections. This review's primary focus is to gather and analyze data from different recent studies about chitosan-based hydrogels combating dermal infections; this includes assessing their ability to inhibit the growth of microorganisms and reduce infection-related symptoms. Furthermore, this review also considers the safety profile of chitosan-based hydrogels, examining any potential adverse effects associated with their use. This evaluation is crucial to ensure that these hydrogels can be safely utilized in the management of dermal infections without causing harm to patients. The review aims to provide healthcare professionals and researchers with a comprehensive understanding of the current evidence regarding the use of chitosan-based hydrogels for dermal infection management. The findings from this review can contribute to informed decision-making and the development of potential treatment strategies in this field.

摘要

本综述的主要目的是全面概述目前有关使用壳聚糖基水凝胶治疗皮肤感染的证据。壳聚糖是一种从几丁质衍生而来的天然多糖，具有固有的抗菌特性，使其成为治疗各种皮肤感染的有前景的候选物。本综述采用系统的方法来分析相关研究，这些研究探讨了壳聚糖基水凝胶在皮肤感染方面的有效性。通过审查现有证据，本综述旨在评估这些水凝胶在治疗皮肤感染方面的总体疗效、安全性和潜在应用。本综述的主要重点是收集和分析来自不同近期研究的关于壳聚糖基水凝胶对抗皮肤感染的数据；这包括评估它们抑制微生物生长和减轻感染相关症状的能力。此外，本综述还考虑壳聚糖基水凝胶的安全性，检查与其使用相关的任何潜在不良反应。这种评估对于确保这些水凝胶能够安全地用于治疗皮肤感染而不对患者造成伤害至关重要。本综述旨在为医疗保健专业人员和研究人员提供关于使用壳聚糖基水凝胶治疗皮肤感染的当前证据的全面理解。本综述的结果可为该领域的明智决策和潜在治疗策略的开发做出贡献。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c66/10379151/ad9cba885566/gels-09-00594-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c66/10379151/861d42c541e5/gels-09-00594-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c66/10379151/6a0f7c32a2d2/gels-09-00594-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c66/10379151/3005d299ed64/gels-09-00594-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c66/10379151/7f67b4b042ea/gels-09-00594-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c66/10379151/0177fd3b1a1e/gels-09-00594-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c66/10379151/3cd89688e2f2/gels-09-00594-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c66/10379151/c80afd0c8fcf/gels-09-00594-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c66/10379151/ea0e1b75cf81/gels-09-00594-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c66/10379151/ad9cba885566/gels-09-00594-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c66/10379151/861d42c541e5/gels-09-00594-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c66/10379151/6a0f7c32a2d2/gels-09-00594-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c66/10379151/3005d299ed64/gels-09-00594-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c66/10379151/7f67b4b042ea/gels-09-00594-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c66/10379151/0177fd3b1a1e/gels-09-00594-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c66/10379151/3cd89688e2f2/gels-09-00594-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c66/10379151/c80afd0c8fcf/gels-09-00594-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c66/10379151/ea0e1b75cf81/gels-09-00594-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c66/10379151/ad9cba885566/gels-09-00594-g009.jpg

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