Naganawa Shinji, Sato Chiho, Nakamura Tatsuya, Kumada Hisashi, Ishigaki Takeo, Miura Shunichi, Maruyama Katsuya, Takizawa Osamu
Department of Radiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
J Magn Reson Imaging. 2005 Jun;21(6):836-40. doi: 10.1002/jmri.20346.
To study the recognition of malignant lesions of the liver on diffusion-weighted images (DWI) can be improved by the administration of superparamagnetic iron oxide (SPIO).
Pre- and post-SPIO mediated DWI of the liver was compared in six patients with suspected malignant liver lesions at 1.5 Tesla using a parallel imaging technique.
Post-SPIO DWI showed improved contrast-to-noise ratio between malignant lesions and liver. Furthermore, the spleen signal was decreased on post-SPIO DWI, thus avoiding the overlap of the spleen and left lobe of the liver on maximum intensity projections (MIP).
Recognition of malignant lesions of the liver was improved by SPIO on DWI. On MIP images of DWI, SPIO helped to decrease the overlap of spleen signal on the liver in some projection angles.
研究通过给予超顺磁性氧化铁（SPIO）能否提高在扩散加权成像（DWI）上对肝脏恶性病变的识别能力。
在1.5特斯拉场强下，使用并行成像技术对6例疑似肝脏恶性病变患者在注射SPIO前后进行肝脏DWI检查，并对结果进行比较。
注射SPIO后的DWI显示恶性病变与肝脏之间的对比噪声比有所提高。此外，注射SPIO后的DWI上脾脏信号降低，从而避免了在最大强度投影（MIP）图像上脾脏与肝脏左叶的信号重叠。
SPIO可提高DWI上对肝脏恶性病变的识别能力。在DWI的MIP图像上，SPIO有助于在某些投影角度减少脾脏信号在肝脏上的重叠。
