Stanley Theodore H
University of Utah Health Sciences Center, Salt Lake City, Utah 84132, USA.
J Pain Symptom Manage. 2005 May;29(5 Suppl):S67-71. doi: 10.1016/j.jpainsymman.2005.01.009.
Fentanyl, a potent lipid-soluble opioid which was first synthesized more than 40 years ago, is still the most popular opioid used in the perioperative period throughout the world. Fentanyl's introduction, versatility, and popularity have resulted in its use in many acute and chronic pain conditions and a multitude of novel delivery systems in the last two decades. In spite of the development of more potent, safer, faster onset, and both shorter and longer lasting alternative opioids, fentanyl remains the mainstay of anesthesiologists and Certified Registered Nurse Anesthetists in the perioperative period, and for many pain physicians throughout the world.
芬太尼是一种强效的脂溶性阿片类药物，40多年前首次合成，至今仍是全球围手术期最常用的阿片类药物。在过去二十年中，芬太尼的问世、多功能性和广泛应用使其被用于许多急慢性疼痛病症以及多种新型给药系统。尽管已研发出效力更强、更安全、起效更快、作用时长有短有长的替代性阿片类药物，但芬太尼仍是麻醉医生和注册麻醉护士在围手术期的主要用药，也是全球众多疼痛科医生的常用药。
