格菲霉素，首个桥连安古环素类化合物，源自灰色链霉菌NTK 14菌株。
Gephyromycin, the first bridged angucyclinone, from Streptomyces griseus strain NTK 14.
作者信息
Bringmann Gerhard, Lang Gerhard, Maksimenka Katja, Hamm Andreas, Gulder Tobias A M, Dieter Anke, Bull Alan T, Stach James E M, Kocher Niko, Müller Werner E G, Fiedler Hans-Peter
机构信息
Institut für Organische Chemie, Universität Würzburg, Am Hubland, D-97074 Würzburg, Germany.
出版信息
Phytochemistry. 2005 Jun;66(11):1366-73. doi: 10.1016/j.phytochem.2005.04.010.
The new, highly oxygenated angucyclinone gephyromycin was isolated from an extract of a Streptomyces griseus strain. Its unprecedented ether-bridged structure was elucidated by NMR methods and substantiated by single crystal X-ray analysis. The absolute configuration was evidenced by quantum chemical CD calculations. Gephyromycin exhibits glutaminergic activity towards neuronal cells. Furthermore, the known compounds fridamycin E and dehydrorabelomycin were identified.
新型的、高度氧化的安古环素类杰菲霉素是从灰色链霉菌菌株的提取物中分离得到的。通过核磁共振方法阐明了其前所未有的醚桥结构，并通过单晶X射线分析得到证实。通过量子化学圆二色性计算确定了其绝对构型。杰菲霉素对神经元细胞表现出谷氨酰胺能活性。此外，还鉴定出了已知化合物弗里达霉素E和脱水拉贝霉素。
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