Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.
Laboratory for Marine Drugs and Bioproducts, Pilot National Laboratory for Marine Science and Technology (Qingdao), Qingdao 266237, China.
Mar Drugs. 2022 Feb 13;20(2):137. doi: 10.3390/md20020137.
Five new sesquiterpenoids, citreobenzofuran D-F (-) and phomenone A-B (-), along with one known compound, xylarenone A (), were isolated from the culture of the mangrove-derived fungus sp. HDN13-494. Their structures were deduced from extensive spectroscopic data, high-resolution electrospray ionization mass spectrometry (HRESIMS), and electronic circular dichroism (ECD) calculations. Furthermore, the absolute structures of were determined by single-crystal X-ray diffraction analysis. Citreobenzofuran E-F (-) are eremophilane-type sesquiterpenoids with rare benzofuran frameworks, while phomenone A () contains a rare thiomethyl group, which is the first report of this kind of sesquiterpene with sulfur elements in the skeleton. All the compounds were tested for their antimicrobial and antitumor activity, and phomenone B () showed moderate activity against with an MIC value of 6.25 μM.
从红树林来源的真菌 sp. HDN13-494 的培养物中分离得到了五个新的倍半萜类化合物，包括 citreobenzofuran D-F (-) 和 phomenone A-B (-)，以及一个已知化合物 xylarenone A (). 它们的结构是通过广泛的光谱数据分析、高分辨率电喷雾电离质谱 (HRESIMS) 和电子圆二色性 (ECD) 计算推断出来的。此外，通过单晶 X 射线衍射分析确定了 的绝对结构。Citreobenzofuran E-F (-) 是具有罕见苯并呋喃骨架的埃雷莫芬烷型倍半萜，而 phomenone A () 含有罕见的硫甲基，这是骨架中含有硫元素的这种倍半萜的首次报道。所有化合物均进行了抗菌和抗肿瘤活性测试，phomenone B () 对 显示出中等活性，MIC 值为 6.25 μM。
