Kaur Kamaljit, Michael Husheem, Arora Saroj, Härkönen Pirkko, Kumar Subodh
Department of Botanical and Environmental Sciences, Guru Nanak Dev University, Amritsar 143005, India.
J Ethnopharmacol. 2005 Jul 14;99(3):353-60. doi: 10.1016/j.jep.2005.01.040.
The present study was undertaken to evaluate antimutagenic and cytotoxic effects of different extracts/fractions of Acacia nilotica prepared by maceration method. The potency order of different extracts was more or less similar in Ames assay as well as in cytotoxic assay. Considering the maximum potential of acetone extract in both the assays, the studies were initiated to fractionate this extract. Two pure fractions, namely AN-1 and AN-2, were obtained from acetone extract, of which AN-2 was found to be of gallic acid and AN-1 fraction is still to be identified. In conclusion, the antimutagenic and cytotoxic activities exhibited by acetone extract may partially be ascribed to the presence of gallic acid and other polyphenols.
本研究旨在评估采用浸渍法制备的阿拉伯胶不同提取物/馏分的抗诱变和细胞毒性作用。不同提取物在艾姆斯试验和细胞毒性试验中的效力顺序大致相似。鉴于丙酮提取物在这两种试验中的最大潜力，开始对该提取物进行分馏。从丙酮提取物中获得了两个纯馏分，即AN - 1和AN - 2，其中发现AN - 2是没食子酸，而AN - 1馏分仍有待鉴定。总之，丙酮提取物表现出的抗诱变和细胞毒性活性可能部分归因于没食子酸和其他多酚的存在。
