Ikeda Ikuo, Hamamoto Reina, Uzu Kazunori, Imaizumi Katsumi, Nagao Koji, Yanagita Teruyoshi, Suzuki Yuko, Kobayashi Makoto, Kakuda Takami
Laboratory of Nutrition Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School, Kyushu University, Fukuoka, Japan.
Biosci Biotechnol Biochem. 2005 May;69(5):1049-53. doi: 10.1271/bbb.69.1049.
Tea catechins, rich in (-)-epigallocatechin gallate and (-)-epicatechin gallate, or heat-treated tea catechins in which about 50% of the (-)-epigallocatechin gallate and (-)-epicatechin gallate in tea catechins was epimerized to (-)-gallocatechin gallate and (-)-catechin gallate, were fed to rats at 1% level for 23 d. Visceral fat deposition and the concentration of hepatic triacylglycerol were significantly lower in the tea catechin and heat-treated tea catechin groups than in the control group. The activities of fatty acid synthase and the malic enzyme in the liver cytosol were significantly lower in the two catechin groups than in the control group. In contrast, the activities of carnitine palmitoyltransferase and acyl-CoA oxidase in the liver homogenate were not significantly different among the three groups. These results suggest that the reduction in activities of enzymes related to hepatic fatty acid synthesis by the feeding of tea catechins or heat-treated tea catechins can cause reductions of hepatic triacylglycerol and possibly of visceral fat deposition.
富含（-）-表没食子儿茶素没食子酸酯和（-）-表儿茶素没食子酸酯的茶儿茶素，或其中茶儿茶素中约50%的（-）-表没食子儿茶素没食子酸酯和（-）-表儿茶素没食子酸酯差向异构化为（-）-没食子儿茶素没食子酸酯和（-）-儿茶素没食子酸酯的热处理茶儿茶素，以1%的水平喂饲大鼠23天。茶儿茶素组和热处理茶儿茶素组的内脏脂肪沉积和肝脏三酰甘油浓度显著低于对照组。两个儿茶素组肝脏胞质溶胶中脂肪酸合酶和苹果酸酶的活性显著低于对照组。相比之下，三组肝脏匀浆中肉碱棕榈酰转移酶和酰基辅酶A氧化酶的活性无显著差异。这些结果表明，通过喂饲茶儿茶素或热处理茶儿茶素降低肝脏脂肪酸合成相关酶的活性可导致肝脏三酰甘油减少，并可能导致内脏脂肪沉积减少。
