Wu Tao, Xu Jinling, Chen Yijun, Liu Rui, Zhang Min
Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Technology and Business University, Beijing, China.
State Key Laboratory of Food Nutrition and Safety, Tianjin University of Science and Technology, Tianjin, China.
Food Nutr Res. 2018 Dec 19;62. doi: 10.29219/fnr.v62.1599. eCollection 2018.
Several studies have evaluated the effects of oolong tea extracts on obesity. However, only few studies focused on the anti-obesity effect of specific components of oolong tea.
This study investigated the specific anti-obesity capabilities of oolong tea polysaccharide (TPS) and tea polyphenols (TPP) in high-fat diet-induced Sprague-Dawley rats.
Oolong tea water extract, TPS, TPP, and polysaccharide mixed with polyphenol (TPSM) given at doses of 400 or 800 mg/kg were administered to rats fed with high-fat diet for 6 weeks to explore the anti-obesity effects of the treatments.
TPS and TPP were responsible for the suppressive effect on body fat accumulation. TPSM exhibited the highest effect on body weight reduction, and TPS and TPP effectively reduced serum leptin levels and significantly improved blood lipid and antioxidant levels. Moreover, microarray analysis of hepatic and adipose gene expression profiles revealed that TPP and TPS inhibited obesity through effects on the pathways of fatty acid biosynthesis, steroid hormone biosynthesis, unsaturated fatty acid biosynthesis, fatty acid elongation, glycerolipid metabolism, and glycerophospholipid metabolism.
TPSM might be a potential therapy for the treatment of obesity.
多项研究评估了乌龙茶提取物对肥胖的影响。然而，仅有少数研究关注乌龙茶特定成分的抗肥胖作用。
本研究调查了乌龙茶多糖（TPS）和茶多酚（TPP）对高脂饮食诱导的Sprague-Dawley大鼠的特定抗肥胖能力。
将剂量为400或800 mg/kg的乌龙茶水提取物、TPS、TPP以及多糖与多酚混合物（TPSM）给予高脂饮食喂养6周的大鼠，以探究这些处理的抗肥胖效果。
TPS和TPP对体脂积累具有抑制作用。TPSM对体重减轻的效果最为显著，TPS和TPP有效降低了血清瘦素水平，并显著改善了血脂和抗氧化水平。此外，对肝脏和脂肪基因表达谱的微阵列分析表明，TPP和TPS通过影响脂肪酸生物合成、类固醇激素生物合成、不饱和脂肪酸生物合成、脂肪酸延长、甘油酯代谢和甘油磷脂代谢途径来抑制肥胖。
TPSM可能是治疗肥胖的一种潜在疗法。
