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Blunted prolactin responses to d-fenfluramine in sociopathy. Evidence for subsensitivity of central serotonergic function.

作者信息

O'Keane V, Moloney E, O'Neill H, O'Connor A, Smith C, Dinan T G

机构信息

Psychiatric Unit, St James's Hospital, Dublin, Republic of Ireland.

出版信息

Br J Psychiatry. 1992 May;160:643-6. doi: 10.1192/bjp.160.5.643.

DOI:10.1192/bjp.160.5.643
PMID:1591573
Abstract

Using a neuroendocrine probe we studied nine male offenders in a forensic hospital, convicted of murder, with a diagnosis of antisocial personality disorder, who had been behaviourally 'quiescent' for varying periods and who had not recently been abusing drugs. Nine healthy age-matched men also participated. All subjects received 30 mg d-fenfluramine (d-FEN), a 5-HT releasing agent, orally, after an overnight fast, and serial samples for prolactin estimation were taken hourly for five hours. Responses were significantly impaired in the patients, suggesting a subsensitivity of certain 5-HT systems in antisocial personality disorder, regardless of recent or ongoing behavioural disturbance.

摘要

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