McGeer Patrick L, Sibley John
Kinsmen Laboratory of Neurological Research, University of British Columbia, Vancouver, Canada.
Neurobiol Aging. 2005 Aug-Sep;26(8):1199-203. doi: 10.1016/j.neurobiolaging.2005.02.003. Epub 2005 Apr 19.
Age-related macular degeneration (AMD), for which inflammatory changes have been demonstrated, is the commonest cause of blindness in the elderly. We compared the prevalence of AMD in a prospectively followed cohort of rheumatoid arthritic (RA) patients from Saskatchewan with published data from four racially similar general populations. For individuals 65 years or older, only three cases of AMD were identified in the Saskatchewan cohort of 993 RA patients (0.2% prevalence). This compares with 67 out of 1955 subjects in the Beaver Dam survey (prevalence 3.43%); 101 out of 4071 in the Rotterdam survey (prevalence 2.48%); and 63 out of 1950 in the Blue Mountains survey (prevalence 3.23%). For individuals 75 years or older, only two cases out of 497 were identified in the RA cohort (prevalence 0.40%), compared with 516 cases out of 13,900 in the United Kingdom survey (prevalence 3.72%). Patients with RA appear to be relatively spared from AMD. We hypothesize that this results from long term antiinflammatory treatment. Genetic or environmental factors could also be responsible.
年龄相关性黄斑变性（AMD）是老年人失明的最常见原因，已有研究证实其存在炎症变化。我们将来自萨斯喀彻温省的类风湿关节炎（RA）患者前瞻性队列中AMD的患病率与四个种族相似的普通人群的已发表数据进行了比较。对于65岁及以上的个体，在993名RA患者的萨斯喀彻温省队列中仅发现3例AMD（患病率0.2%）。相比之下，比弗戴尔调查中1955名受试者中有67例（患病率3.43%）；鹿特丹调查中4071名中有101例（患病率2.48%）；蓝山调查中1950名中有63例（患病率3.23%）。对于75岁及以上的个体，在RA队列的497名中仅发现2例（患病率0.40%），而英国调查中13900名中有516例（患病率3.72%）。RA患者似乎相对较少患AMD。我们推测这是长期抗炎治疗的结果。遗传或环境因素也可能起作用。
