Montaño-Loza Aldo, Schmulson Max, Zepeda-Gómez Sergio, Remes-Troche Jose Maria, Valdovinos-Diaz Miguel Angel
Department of Gastroenterology, Instituto Nacional de Ciencias Medicas y Nutricion, Salvador Zubiran, Vasco de Quiroga # 15, Tlalpan, CP 14000, México DF.
World J Gastroenterol. 2005 May 28;11(20):3122-6. doi: 10.3748/wjg.v11.i20.3122.
Recently, drinking load tests with water or nutritional beverages have been proposed as diagnostic tools for functional dyspepsia (FD), therefore we sought to reproduce if these tests can discriminate between FD patients and controls in a Mexican population.
Twenty FD-Rome II patients were matched by age and gender with 20 healthy controls. All underwent both drinking tests at a 15 mL/min rate, randomly, 7 d apart. Every 5 min within each test, four symptoms were evaluated (satiety, bloating, nausea and pain) by Likert scales. Maximum tolerated volume (MTV) was defined as the ingested volume when a score of 5 was reached for any symptom or when the test had to be stopped because the patients could not tolerate more volume. Sensitivity and specificity were analyzed.
FD patients had higher symptom scores for both tests compared to controls (water: t = 4.1, P = 0.001<0.01; Nutren: t = 5.2, P = 0.001<0.01). The MTV for water and Nutren were significantly lower in FD (water: 1 014+/-288 vs 1 749+/-275 mL; t = 7.9, P = 0.001<0.01; Nutren: 652+/-168 vs 1 278+/-286 mL; t = 6.7, P = 0.001<0.01). With the volume tolerated by the controls, the percentile 10 was determined as the lower limit for tolerance. Sensitivity and specificity were 0.90, 0.95 for water and 0.95, 0.95 for Nutren tests.
A drinking test with water or a nutritional beverage can discriminate between FD patients and healthy subjects in Mexico, with high sensitivity and specificity. These tests could be used as objective, noninvasive, and safe diagnostic approaches for FD patients.
最近，有人提出用水或营养饮料进行饮水负荷试验作为功能性消化不良（FD）的诊断工具，因此我们试图重现这些试验能否在墨西哥人群中区分FD患者和对照组。
20名罗马II型FD患者按年龄和性别与20名健康对照匹配。所有人均以15 mL/分钟的速率随机进行两种饮水试验，间隔7天。在每次试验中，每5分钟通过李克特量表评估四种症状（饱腹感、腹胀、恶心和疼痛）。最大耐受量（MTV）定义为当任何症状达到5分或因患者无法耐受更多容量而必须停止试验时的摄入容量。分析敏感性和特异性。
与对照组相比，FD患者在两种试验中的症状评分更高（水：t = 4.1，P = 0.001<0.01；能全力：t = 5.2，P = 0.001<0.01）。FD患者水和能全力的MTV显著更低（水：1014±288 vs 1749±275 mL；t = 7.9，P = 0.001<0.01；能全力：652±168 vs 1278±286 mL；t = 6.7，P = 0.001<0.01）。以对照组耐受的容量确定第10百分位数作为耐受下限。水试验的敏感性和特异性分别为0.90、0.95，能全力试验的敏感性和特异性分别为0.95、0.95。
用水或营养饮料进行的饮水试验能够在墨西哥区分FD患者和健康受试者，具有高敏感性和特异性。这些试验可作为FD患者客观、无创且安全的诊断方法。
