Kindt S, Coulie B, Wajs E, Janssens J, Tack J
Center for Gastroenterological Research, University of Leuven, K.U. Leuven, Belgium.
Neurogastroenterol Motil. 2008 Apr;20(4):320-9. doi: 10.1111/j.1365-2982.2008.01092.x.
Impaired accommodation to a meal has been recognized as a pathophysiological mechanism in functional dyspepsia (FD). Based on observations in tertiary care patients, the drinking test has been proposed as a non-invasive tool to estimate accommodation. Our aim was to assess the reproducibility of the drinking test and its correlation with demographic, symptomatic and pathophysiological parameters in secondary care FD patients and healthy controls. Thirty-four healthy controls and 78 FD patients completed a drinking test (3 respectively 2 times), a gastric emptying study and an FD symptom questionnaire. Factors influencing maximal volume and gastric emptying were determined, and the reproducibility of the drinking test was investigated. The maximal satiety was reached at a lower volume in patients (489 +/- 276 and 503 +/- 248 mL for first and second test respectively vs 937 +/- 428 and 1048 +/- 421 mL, P < 0.0001). The ingested amount depended on age, sex and baseline FD symptom score. Patients' sex, final satiety score, total score for stomach complaints at screening and total symptom score before test accounted for the total symptom score after the test. The slow nutrient drinking test confirms its possible role as an attractive non-invasive and reproducible tool for the diagnosis of impaired accommodation and for the assessment of treatment responsiveness.
对进餐的适应性受损已被认为是功能性消化不良（FD）的一种病理生理机制。基于对三级护理患者的观察，饮水试验已被提议作为一种评估适应性的非侵入性工具。我们的目的是评估饮水试验在二级护理FD患者和健康对照中的可重复性及其与人口统计学、症状和病理生理参数的相关性。34名健康对照者和78名FD患者完成了一项饮水试验（分别进行3次和2次）、一项胃排空研究以及一份FD症状问卷。确定了影响最大容量和胃排空的因素，并研究了饮水试验的可重复性。患者达到最大饱腹感时的容量较低（第一次和第二次试验分别为489±276和503±248 mL，而对照者为937±428和1048±421 mL，P<0.0001）。摄入的量取决于年龄、性别和基线FD症状评分。患者的性别、最终饱腹感评分、筛查时胃部不适的总分以及试验前的总症状评分可解释试验后的总症状评分。缓慢营养饮水试验证实了其作为一种有吸引力的非侵入性且可重复的工具在诊断适应性受损和评估治疗反应性方面的潜在作用。
