Sekar D Sathish, Sivagnanam K, Subramanian S
Department of Biochemistry and Molecular Biology, University of Madras, India.
Pharmazie. 2005 May;60(5):383-7.
The present study was aimed to evaluate the hypoglycemic efficacy in an aqueous extract of seeds of two varieties, namely a country and a hybrid variety of Momordica charantia (MCSEt1 and MCSEt2) respectively in streptozotocin (STZ) induced diabetic rats. STZ-induced diabetic rats were treated with aqueous extracts of MCSEt1 and t2 for a period of 30 days. MCSEt1 and t2 extract treatment to diabetic rats resulted in a significant reduction in blood glucose, glycosylated hemoglobin, lactate dehydrogenase, glucose-6-phosphatase, fructose-1,6-bisphosphatase and glycogen phosphorylase, and a concomitant increase in the levels of hemoglobin, glycogen and activities of hexokinase and glycogen synthase. These results clearly show the antidiabetic properties of Momordica charantia. Both the varieties showed safe and significant hypoglycemic effects which were more pronounced in MCSEt1 compared to MCSEt2 and glibenclamide.
本研究旨在评估两种品种（分别为乡村品种和杂交品种的苦瓜种子水提取物，即MCSEt1和MCSEt2）对链脲佐菌素（STZ）诱导的糖尿病大鼠的降血糖功效。用MCSEt1和t2的水提取物对STZ诱导的糖尿病大鼠进行为期30天的治疗。用MCSEt1和t2提取物治疗糖尿病大鼠后，血糖、糖化血红蛋白、乳酸脱氢酶、葡萄糖-6-磷酸酶、果糖-1,6-二磷酸酶和糖原磷酸化酶显著降低，同时血红蛋白、糖原水平以及己糖激酶和糖原合酶活性增加。这些结果清楚地表明了苦瓜的抗糖尿病特性。两个品种均显示出安全且显著的降血糖作用，与MCSEt2和格列本脲相比，MCSEt1的作用更明显。
