Oluba Olarewaju M, Adebiyi Feyikemi D, Dada Ajibola A, Ajayi Adeyinka A, Adebisi Kayode E, Josiah Sunday J, Odutuga Adewale A
Food Safety and Toxicology Research Unit Environment and Technology Research Cluster Department of Biological Sciences College of Science and Engineering Landmark University Omu Aran Kwara State Nigeria.
Department of Chemical Sciences Joseph Ayo Babalola University Ikeji Arakeji Osun State Nigeria.
Food Sci Nutr. 2018 Oct 11;7(2):385-394. doi: 10.1002/fsn3.765. eCollection 2019 Feb.
leaf flavonoid extract (TTFE) was evaluated for its effects on streptozotocin-hyperglycemia and associated complications especially as it relates to dyslipidemia, lipid peroxidation, and renal dysfunction in rats. Two normoglycemic rat groups designated: control (administered distilled water) and control + TTFE (administered 10 mg/kg b.w. TTFE) and two streptozotocin-induced (STZ) diabetic rat groups designated: STZ-control (administered distilled water) and STZ + TTFE (administered 10 mg/kg TTFE). The treatment was given orally once daily for 21 consecutive days. Body weight and insulin concentration showed significant improvement while blood glucose, uric acid, creatinine, and total bilirubin concentrations were significantly reduced in diabetic rats administered TTFE compared to diabetic untreated rats. Furthermore, triglycerides, total cholesterol, LDL-cholesterol, and malondialdehyde concentrations were significantly lowered in diabetic rats administered TTFE compared with diabetic untreated rats. Key enzymes involved in carbohydrate breakdown and cholesterol synthesis, α-amylase and 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase, respectively, were significantly inhibited in TTFE-treated diabetic rats compared to diabetic control. Results presented in this study suggest that administration of TTFE for 21 days normalized STZ-induced hyperglycemia and its associated dyslipidemia by a mechanism involving inhibition of α-amylase and HMG-CoA reductase activities, respectively, in rats.
对叶黄酮提取物（TTFE）进行了评估，以研究其对链脲佐菌素诱导的高血糖及其相关并发症的影响，特别是与大鼠血脂异常、脂质过氧化和肾功能障碍的关系。将两组血糖正常的大鼠分为：对照组（给予蒸馏水）和对照组 + TTFE组（给予10 mg/kg体重的TTFE）；将两组链脲佐菌素诱导的（STZ）糖尿病大鼠分为：STZ对照组（给予蒸馏水）和STZ + TTFE组（给予10 mg/kg的TTFE）。连续21天每天口服给药一次。与未治疗的糖尿病大鼠相比，给予TTFE的糖尿病大鼠体重和胰岛素浓度有显著改善，而血糖、尿酸、肌酐和总胆红素浓度显著降低。此外，与未治疗的糖尿病大鼠相比，给予TTFE的糖尿病大鼠甘油三酯、总胆固醇、低密度脂蛋白胆固醇和丙二醛浓度显著降低。与糖尿病对照组相比，TTFE治疗的糖尿病大鼠中参与碳水化合物分解和胆固醇合成的关键酶，即α-淀粉酶和3-羟基-3-甲基戊二酰辅酶A（HMG-CoA）还原酶，分别受到显著抑制。本研究结果表明，在大鼠中，连续21天给予TTFE可通过分别抑制α-淀粉酶和HMG-CoA还原酶活性的机制，使STZ诱导的高血糖及其相关的血脂异常恢复正常。
