体外受精后透明带厚度与临床妊娠结局
Zona pellucida thickness and clinical pregnancy outcome following in vitro fertilization.
作者信息
Sun Y P, Xu Y, Cao T, Su Y C, Guo Y H
机构信息
Reproductive medical unit, Department of Obstetrics and Gynaecology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
出版信息
Int J Gynaecol Obstet. 2005 Jun;89(3):258-62. doi: 10.1016/j.ijgo.2005.02.012. Epub 2005 Apr 7.
OBJECTIVE
To investigate possible correlations of ZPT or ZPTV with clinical outcome following in vitro fertilization.
METHODS
Two hundred forty-six embryos were selected for transfer on day 3 with clear image record from 81 IVF-ET cycles. The laser system measurement software was used to measure the ZTP value of each embryo and the ZPTV was computed. Statistical analysis was done using the ANOVA or Chi-square test.
RESULTS
Both ZPT and ZPTV declined with women's age. The mean ZPTV of embryos from patients between 30 and 34 years old was significantly higher than that from patients older than 35 (P<0.001). The ZPTV in pregnancy group was significantly higher than that in nonpregnancy group (P<0.005). The clinical pregnancy rate in the group with ZPTV more than 20% was significantly higher than that in the group with ZPTV less than 20% (P<0.05). The ZPTV of high grade embryos was significantly higher than that of low grade embryos (P<0.001).
CONCLUSIONS
ZPTV rather than ZPT is an effective parameter to evaluate the embryo quality. Increasing the ZPTV may enhance embryo implantation potential.
目的
探讨体外受精后ZPT或ZPTV与临床结局之间可能存在的相关性。
方法
从81个体外受精-胚胎移植（IVF-ET）周期中选取246个在第3天进行移植且有清晰图像记录的胚胎。使用激光系统测量软件测量每个胚胎的ZTP值并计算ZPTV。采用方差分析或卡方检验进行统计分析。
结果
ZPT和ZPTV均随女性年龄增长而下降。30至34岁患者的胚胎平均ZPTV显著高于35岁以上患者（P<0.001）。妊娠组的ZPTV显著高于非妊娠组（P<0.005）。ZPTV大于20%组的临床妊娠率显著高于ZPTV小于20%组（P<0.05）。优质胚胎的ZPTV显著高于低质量胚胎（P<0.001）。
结论
ZPTV而非ZPT是评估胚胎质量的有效参数。提高ZPTV可能增强胚胎着床潜力。
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