Whitney JoAnne D
Biobehavioral Nursing and Health Systems, University of Washington, School of Nursing, Box 357266, University of Washington, School of Nursing, Seattle, WA 98195, USA.
Nurs Clin North Am. 2005 Jun;40(2):191-205, v. doi: 10.1016/j.cnur.2004.09.002.
Knowledge of normal wound healing and the changes associated with chronic wounds have advanced significantly. Distinct characteristics identified through basic and clinical studies are found in nonhealing wounds, including bacterial and growth factor imbalances, increased inflammatory responses, and proteolytic forces that tip the balance toward tissue degradation rather than repair. This article describes the alterations that reduce healing and that also have important implications for the management of chronic wounds and presents a focus for future developments in wound therapy.
对正常伤口愈合以及与慢性伤口相关变化的认识已经取得了显著进展。通过基础和临床研究确定的不同特征在不愈合伤口中被发现，包括细菌和生长因子失衡、炎症反应增加以及蛋白水解力使平衡倾向于组织降解而非修复。本文描述了那些减少愈合且对慢性伤口管理具有重要意义的改变，并提出了伤口治疗未来发展的重点。
