Jeusette Isabelle C, Detilleux Johanne, Shibata Haruki, Saito Masayuki, Honjoh Tsutomu, Delobel Agathe, Istasse Louis, Diez Marianne
Affinity-Petcare, 08174, Barcelona, Spain.
Res Vet Sci. 2005 Oct;79(2):169-75. doi: 10.1016/j.rvsc.2004.11.012. Epub 2005 Feb 12.
The objective of this study was to evaluate, in dogs, the effects of obesity and weight loss on plasma total ghrelin and leptin concentrations. Twenty-four Beagle dogs, 12 control lean and 12 obese dogs of both genders and aged between 1 and 9 years, were used for the experiments. Mean body weight was 12.7+/-0.7 kg for the lean group and 21.9+/-0.8 kg for the obese group. The trial was divided into three phases. During phase 1, all 24 Beagle dogs were fed a maintenance diet. During phase 2, the obese dogs were submitted to a weight loss protocol with a high protein-low energy diet. The weight loss protocol ended once dogs reached optimal body weight. During phase 3, the dogs that were submitted to the weight loss protocol were maintained at their optimal body weight for 6 months. Plasma total ghrelin, leptin, insulin and glucose concentrations were measured to evaluate the effects of obesity and weight loss on these parameters in dogs. Body weight, body condition score, thoracic and pelvic perimeters, and ingested food amounts were also recorded during the study. Obese dogs demonstrated a significant decrease in plasma ghrelin and a significant increase in plasma leptin and insulin concentrations when compared with control dogs. During weight loss, significant increases in plasma total ghrelin and glucose and significant decreases in plasma leptin and insulin were observed. The increase in plasma ghrelin concentrations seemed to be transient. Body weight and the morphometric parameters correlated positively with leptin concentrations and negatively with total ghrelin concentrations. These results suggest that ghrelin and leptin could play a role in dogs in the adaptation to a positive or negative energy balance, as observed in humans.
本研究的目的是评估肥胖和体重减轻对犬血浆总胃饥饿素和瘦素浓度的影响。选用24只比格犬，其中12只对照瘦犬和12只肥胖犬，雌雄不限，年龄在1至9岁之间，用于实验。瘦犬组平均体重为12.7±0.7千克，肥胖犬组平均体重为21.9±0.8千克。试验分为三个阶段。在第1阶段，所有24只比格犬均喂食维持性日粮。在第2阶段，肥胖犬采用高蛋白低能量日粮进行减肥方案。一旦犬只达到最佳体重，减肥方案即结束。在第3阶段，接受减肥方案的犬只在其最佳体重维持6个月。测量血浆总胃饥饿素、瘦素、胰岛素和葡萄糖浓度，以评估肥胖和体重减轻对犬这些参数的影响。在研究过程中还记录了体重、身体状况评分、胸周长和腹周长以及摄入的食物量。与对照犬相比，肥胖犬血浆胃饥饿素显著降低，血浆瘦素和胰岛素浓度显著升高。在体重减轻期间，观察到血浆总胃饥饿素和葡萄糖显著增加，血浆瘦素和胰岛素显著降低。血浆胃饥饿素浓度的增加似乎是短暂的。体重和形态学参数与瘦素浓度呈正相关，与总胃饥饿素浓度呈负相关。这些结果表明，正如在人类中观察到的那样，胃饥饿素和瘦素可能在犬适应正能量或负能量平衡中发挥作用。
