心力衰竭的亚硝化应激与药物调节
Nitrosative stress and pharmacological modulation of heart failure.
作者信息
Pacher Pal, Schulz Richard, Liaudet Lucas, Szabó Csaba
机构信息
Laboratory of Physiological Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5625 Fishers Lane MSC 9413, Room 2S24, Bethesda, MD 20892-9413, USA.
出版信息
Trends Pharmacol Sci. 2005 Jun;26(6):302-10. doi: 10.1016/j.tips.2005.04.003.
Abstract
Dysregulation of nitric oxide (NO) and increased oxidative and nitrosative stress are implicated in the pathogenesis of heart failure. Peroxynitrite is a reactive oxidant that is produced from the reaction of nitric oxide with superoxide anion and impairs cardiovascular function through multiple mechanisms, including activation of matrix metalloproteinases (MMPs) and nuclear enzyme poly(ADP-ribose) polymerase (PARP). Recent studies suggest that the neutralization of peroxynitrite or pharmacological inhibition of MMPs and PARP are promising new approaches in the experimental therapy of various forms of myocardial injury. In this article, the role of nitrosative stress and downstream mechanisms, including activation of MMPs and PARP, in various forms of heart failure are discussed and novel emerging therapeutic strategies offered by neutralization of peroxynitrite and inhibition of MMPs and PARP in these pathophysiological conditions are reviewed.
摘要
一氧化氮（NO）失调以及氧化应激和亚硝化应激增加与心力衰竭的发病机制有关。过氧亚硝酸盐是一种活性氧化剂，由一氧化氮与超氧阴离子反应产生，并通过多种机制损害心血管功能，包括激活基质金属蛋白酶（MMPs）和核酶聚（ADP - 核糖）聚合酶（PARP）。最近的研究表明，中和过氧亚硝酸盐或对MMPs和PARP进行药理抑制是各种形式心肌损伤实验性治疗中有前景的新方法。在本文中，讨论了亚硝化应激及其下游机制（包括MMPs和PARP的激活）在各种形式心力衰竭中的作用，并综述了在这些病理生理条件下通过中和过氧亚硝酸盐以及抑制MMPs和PARP提供的新兴治疗策略。
相似文献
1
Nitrosative stress and pharmacological modulation of heart failure.心力衰竭的亚硝化应激与药物调节
Trends Pharmacol Sci. 2005 Jun;26(6):302-10. doi: 10.1016/j.tips.2005.04.003.
2
Drug targets for traumatic brain injury from poly(ADP-ribose)polymerase pathway modulation.通过多聚（ADP-核糖）聚合酶途径调节治疗创伤性脑损伤的药物靶点。
Br J Pharmacol. 2009 Jul;157(5):695-704. doi: 10.1111/j.1476-5381.2009.00229.x. Epub 2009 Apr 9.
3
Role of nitrosative stress and peroxynitrite in the pathogenesis of diabetic complications. Emerging new therapeutical strategies.亚硝化应激和过氧亚硝酸盐在糖尿病并发症发病机制中的作用。新兴的治疗策略。
Curr Med Chem. 2005;12(3):267-75. doi: 10.2174/0929867053363207.
4
Role of superoxide, nitric oxide, and peroxynitrite in doxorubicin-induced cell death in vivo and in vitro.超氧化物、一氧化氮和过氧亚硝酸盐在阿霉素体内外诱导细胞死亡中的作用
Am J Physiol Heart Circ Physiol. 2009 May;296(5):H1466-83. doi: 10.1152/ajpheart.00795.2008. Epub 2009 Mar 13.
5
Role of nitrosative stress and poly(ADP-ribose) polymerase activation in myocardial reperfusion injury.亚硝化应激和聚（ADP-核糖）聚合酶激活在心肌再灌注损伤中的作用。
Curr Vasc Pharmacol. 2005 Jul;3(3):215-20. doi: 10.2174/1570161054368599.
6
Role of redox signaling and poly (adenosine diphosphate-ribose) polymerase activation in vascular smooth muscle cell growth inhibition by nitric oxide and peroxynitrite.氧化还原信号传导和聚（二磷酸腺苷 - 核糖）聚合酶激活在一氧化氮和过氧亚硝酸盐抑制血管平滑肌细胞生长中的作用
J Vasc Surg. 2008 Mar;47(3):599-607. doi: 10.1016/j.jvs.2007.11.006.
7
Role of oxidative-nitrosative stress and downstream pathways in various forms of cardiomyopathy and heart failure.氧化-亚硝化应激及其下游通路在各种心肌病和心力衰竭中的作用。
Curr Vasc Pharmacol. 2005 Jul;3(3):221-9. doi: 10.2174/1570161054368607.
8
Oxidative-nitrosative stress and poly(ADP-ribose) polymerase (PARP) activation in experimental diabetic neuropathy: the relation is revisited.实验性糖尿病神经病变中的氧化亚硝化应激与多聚（ADP - 核糖）聚合酶（PARP）激活：重新审视二者关系
Diabetes. 2005 Dec;54(12):3435-41. doi: 10.2337/diabetes.54.12.3435.
9
Role of Peroxynitrite-Induced Activation of Poly(ADP-Ribose) Polymerase (PARP) in Circulatory Shock and Related Pathological Conditions.过氧亚硝酸盐诱导的多聚（ADP-核糖）聚合酶（PARP）激活在循环休克及相关病理状况中的作用。
Cardiovasc Toxicol. 2017 Oct;17(4):373-383. doi: 10.1007/s12012-016-9394-7.
10
Role of nitric oxide, superoxide, peroxynitrite and PARP in diabetic retinopathy.一氧化氮、超氧化物、过氧亚硝酸盐和聚（ADP-核糖）聚合酶在糖尿病视网膜病变中的作用。
Front Biosci (Landmark Ed). 2009 Jan 1;14(10):3974-87. doi: 10.2741/3505.
引用本文的文献
1
Molecular and Biochemical Mechanisms of Cardiomyopathy Development Following Prenatal Hypoxia-Focus on the NO System.产前缺氧后心肌病发展的分子和生化机制——聚焦于一氧化氮系统
Antioxidants (Basel). 2025 Jun 16;14(6):743. doi: 10.3390/antiox14060743.
2
PCSK9, A Promising Novel Target for Age-Related Cardiovascular Dysfunction.前蛋白转化酶枯草溶菌素9，一种治疗年龄相关性心血管功能障碍的潜在新靶点。
JACC Basic Transl Sci. 2023 Sep 13;8(10):1334-1353. doi: 10.1016/j.jacbts.2023.06.005. eCollection 2023 Oct.
3
PARP2 poly(ADP-ribosyl)ates nuclear factor erythroid 2-related factor 2 (NRF2) affecting NRF2 subcellular localization.PARP2 多聚（ADP-核糖）化核因子红细胞 2 相关因子 2（NRF2），影响 NRF2 的亚细胞定位。
Sci Rep. 2023 May 15;13(1):7869. doi: 10.1038/s41598-023-35076-w.
4
Icariin ameliorates oxidative stress-induced inflammation, apoptosis, and heart failure in isoproterenol-challenged Wistar rats.淫羊藿苷改善异丙肾上腺素所致Wistar大鼠氧化应激诱导的炎症、凋亡及心力衰竭。
Iran J Basic Med Sci. 2023;26(5):517-525. doi: 10.22038/IJBMS.2023.66481.14589.
5
Antioxidant and Anticholinesterase Properties of the Aqueous Extract of L. Delile Fruit Pulp on Monosodium Glutamate-Induced Excitotoxicity in Swiss Mice.德利乳杆菌果实果肉水提取物对味精诱导的瑞士小鼠兴奋性毒性的抗氧化和抗胆碱酯酶特性
Evid Based Complement Alternat Med. 2022 Apr 11;2022:7576132. doi: 10.1155/2022/7576132. eCollection 2022.
6
Involvement of Oxidative Stress in the Development of Subcellular Defects and Heart Disease.氧化应激在亚细胞缺陷和心脏病发生发展中的作用。
Biomedicines. 2022 Feb 7;10(2):393. doi: 10.3390/biomedicines10020393.
7
Atypical antipsychotics and oxidative cardiotoxicity: review of literature and future perspectives to prevent sudden cardiac death.非典型抗精神病药物与氧化心脏毒性：文献综述及预防心源性猝死的未来展望
J Geriatr Cardiol. 2021 Aug 28;18(8):663-685. doi: 10.11909/j.issn.1671-5411.2021.08.002.
8
Implications of Oxidative and Nitrosative Post-Translational Modifications in Therapeutic Strategies against Reperfusion Damage.氧化和亚硝化翻译后修饰在抗再灌注损伤治疗策略中的意义
Antioxidants (Basel). 2021 May 8;10(5):749. doi: 10.3390/antiox10050749.
9
Parenteral Nutrition and Cardiotoxicity.肠外营养与心脏毒性。
Cardiovasc Toxicol. 2021 Apr;21(4):265-271. doi: 10.1007/s12012-021-09638-1. Epub 2021 Feb 7.
10
Salivary Gland Dysfunction in Patients with Chronic Heart Failure Is Aggravated by Nitrosative Stress, as Well as Oxidation and Glycation of Proteins.慢性心力衰竭患者的唾液腺功能障碍会因亚硝化应激以及蛋白质的氧化和糖基化而加重。
Biomolecules. 2021 Jan 18;11(1):119. doi: 10.3390/biom11010119.
本文引用的文献
1
NO/redox disequilibrium in the failing heart and cardiovascular system.衰竭心脏和心血管系统中的一氧化氮/氧化还原失衡。
J Clin Invest. 2005 Mar;115(3):509-17. doi: 10.1172/JCI24459.
2
Role of nitrosative stress and peroxynitrite in the pathogenesis of diabetic complications. Emerging new therapeutical strategies.亚硝化应激和过氧亚硝酸盐在糖尿病并发症发病机制中的作用。新兴的治疗策略。
Curr Med Chem. 2005;12(3):267-75. doi: 10.2174/0929867053363207.
3
Poly(ADP-ribose) polymerase regulates myocardial calcium handling in doxorubicin-induced heart failure.聚（ADP - 核糖）聚合酶调节阿霉素诱导的心力衰竭中的心肌钙处理。
Biochem Pharmacol. 2005 Mar 1;69(5):725-32. doi: 10.1016/j.bcp.2004.11.023. Epub 2005 Jan 12.
4
Ischaemia-reperfusion injury activates matrix metalloproteinases in the human heart.缺血再灌注损伤会激活人类心脏中的基质金属蛋白酶。
Eur Heart J. 2005 Jan;26(1):27-35. doi: 10.1093/eurheartj/ehi007. Epub 2004 Nov 30.
5
Endothelial cell activation in patients with decompensated heart failure.失代偿性心力衰竭患者的内皮细胞激活
Circulation. 2005 Jan 4;111(1):58-62. doi: 10.1161/01.CIR.0000151611.89232.3B. Epub 2004 Dec 20.
6
Poly(ADP-Ribose) polymerase promotes cardiac remodeling, contractile failure, and translocation of apoptosis-inducing factor in a murine experimental model of aortic banding and heart failure.在主动脉缩窄和心力衰竭的小鼠实验模型中，聚（ADP - 核糖）聚合酶促进心脏重塑、收缩功能衰竭以及凋亡诱导因子的易位。
J Pharmacol Exp Ther. 2005 Mar;312(3):891-8. doi: 10.1124/jpet.104.077164. Epub 2004 Nov 2.
7
Angiotensin II-mediated endothelial dysfunction: role of poly(ADP-ribose) polymerase activation.血管紧张素II介导的内皮功能障碍：聚（ADP-核糖）聚合酶激活的作用。
Mol Med. 2004 Jan-Jun;10(1-6):28-35. doi: 10.2119/2004-00001.szabo.
8
Contribution of vascular NAD(P)H oxidase to endothelial dysfunction in heart failure and the therapeutic effects of HMG-CoA reductase inhibitor.血管NAD(P)H氧化酶在心力衰竭内皮功能障碍中的作用及HMG-CoA还原酶抑制剂的治疗效果
Circ J. 2004 Nov;68(11):1067-75. doi: 10.1253/circj.68.1067.
9
Increased expression of poly(ADP-ribose) polymerase-1 contributes to caspase-independent myocyte cell death during heart failure.聚（ADP - 核糖）聚合酶 -1表达增加导致心力衰竭期间心肌细胞发生不依赖半胱天冬酶的细胞死亡。
Am J Physiol Heart Circ Physiol. 2005 Feb;288(2):H486-96. doi: 10.1152/ajpheart.00437.2004. Epub 2004 Sep 16.
10
Doxycycline ameliorates ischemic and border-zone remodeling and endothelial dysfunction after myocardial infarction in rats.强力霉素可改善大鼠心肌梗死后的缺血及边缘区重塑和内皮功能障碍。
J Heart Lung Transplant. 2004 Jun;23(6):729-36. doi: 10.1016/j.healun.2003.06.005.
Zotero 插件