Martin R, Delgado J M, Moltò J M, Vicent J M, Manzanares R, Insa R, Matìas-Guiu J
Neurological Department, Hospital Virgen de los Lirios, Alcoy, Spain.
Ital J Neurol Sci. 1992 Mar;13(2):125-9. doi: 10.1007/BF02226960.
Although some authors have reported clinical features of autonomic dysfunction in patients with malignant disease only a few systematic studies have been carried out. We have investigated the autonomic function of 48 patients with carcinoma or lymphoma by testing their cardiovascular reflexes, and compared their results with those of 62 healthy volunteers. Our patients showed a smaller increase in heart rate and a greater fall in blood pressure on standing up, as well as a smaller rise in blood pressure in response to contralateral handgrip. The study group showed a higher percentage of established sympathetic lesion (54.2% vs 27.4%, p: 0.008) and of atypical pattern of global autonomic function impairment (50% vs 24.2%, p: 0.03) than the control group. Our data suggest that patients with malignant disease suffer from a definite autonomic dysfunction.
尽管一些作者报道了恶性疾病患者自主神经功能障碍的临床特征，但仅开展了少数系统性研究。我们通过检测48例癌症或淋巴瘤患者的心血管反射来研究其自主神经功能，并将结果与62名健康志愿者的结果进行比较。我们的患者在站立时心率增加较小，血压下降较大，对侧手握力时血压升高也较小。研究组中已确定的交感神经病变（54.2%对27.4%，p：0.008）和全球自主神经功能损害的非典型模式（50%对24.2%，p：0.03）的百分比高于对照组。我们的数据表明，恶性疾病患者存在明确的自主神经功能障碍。
