梅毒感染兔的黏多糖物质对淋巴细胞对刀豆球蛋白A反应的抑制作用。
Suppression of lymphocyte response to concanavalin A by mucopolysaccharide material from Treponema pallidum-infected rabbits.
作者信息
Bey R F, Johnson R C, Fitzgerald T J
出版信息
Infect Immun. 1979 Oct;26(1):64-9. doi: 10.1128/iai.26.1.64-69.1979.
Abstract
The testicular fluid and serum from rabbits infected intratesticularly with Treponema pallidum inhibited the mitogenic response of normal rabbit peripheral blood lymphocytes to concanavalin A. Mucopolysaccharide material present in the testicular fluid and serum was associated with the lymphocyte-inhibitory activity. Degradation of the mucopolysaccharide material with hyaluronidase resulted in the loss of the inhibitory activity of testicular fluid and serum of T. pallidu-infected rabbits.
摘要
经睾丸内感染梅毒螺旋体的家兔的睾丸液和血清，抑制了正常家兔外周血淋巴细胞对刀豆球蛋白A的促有丝分裂反应。睾丸液和血清中存在的黏多糖物质与淋巴细胞抑制活性有关。用透明质酸酶降解黏多糖物质，导致感染梅毒螺旋体的家兔的睾丸液和血清失去抑制活性。
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