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感染梅毒螺旋体（Nichols株）的家兔对刀豆球蛋白A的淋巴细胞反应受抑制。

Depression of lymphocyte response to concanavalin A in rabbits infected with Treponema pallidum (Nichols strain).

作者信息

Pavia C S, Folds J D, Baseman J B

出版信息

Infect Immun. 1976 Jul;14(1):320-2. doi: 10.1128/iai.14.1.320-322.1976.

DOI:10.1128/iai.14.1.320-322.1976
PMID:780277
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC420882/
Abstract

Peripheral blood lymphocytes isolated from rabbits in the early stages of Treponema pallidum infection responded poorly when exposed to concanavalin A in vitro. Maximal depression of blastogenesis occurred when lymphocytes were cultured in the presence of autologous serum in comparison with fetal calf or normal homologous rabbit serum.

摘要

从梅毒螺旋体感染早期的兔子中分离出的外周血淋巴细胞，在体外暴露于刀豆球蛋白A时反应不佳。与胎牛血清或正常同源兔血清相比，当淋巴细胞在自体血清存在的情况下培养时，母细胞生成的最大抑制作用出现。

相似文献

1
Depression of lymphocyte response to concanavalin A in rabbits infected with Treponema pallidum (Nichols strain).感染梅毒螺旋体（Nichols株）的家兔对刀豆球蛋白A的淋巴细胞反应受抑制。
Infect Immun. 1976 Jul;14(1):320-2. doi: 10.1128/iai.14.1.320-322.1976.
2
Cell-mediated immunity in Treponema pallidum infected rabbits: in vitro response of splenic and lymph node lymphocytes to mitogens and specific antigens.梅毒螺旋体感染兔的细胞介导免疫：脾和淋巴结淋巴细胞对有丝分裂原和特异性抗原的体外反应
Clin Exp Immunol. 1980 Jan;39(1):38-43.
3
Selective in vitro response of thymus-derived lymphocytes from Treponema pallidum-infected rabbits.梅毒螺旋体感染兔胸腺来源淋巴细胞的体外选择性反应。
Infect Immun. 1977 Dec;18(3):603-11. doi: 10.1128/iai.18.3.603-611.1977.
4
Modulation of normal lymphocyte stimulation by serum from Treponema pallidum-infected rabbits.
Cell Immunol. 1980 Jul 15;53(1):29-38. doi: 10.1016/0008-8749(80)90423-2.
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Characterization of lymphocyte responsiveness in early experimental syphilis. I. In vitro response to mitogens and Treponema pallidum antigens.早期实验性梅毒中淋巴细胞反应性的特征。I. 对有丝分裂原和梅毒螺旋体抗原的体外反应
J Immunol. 1980 Jan;124(1):454-60.
6
Reappraisal of lymphocyte responsiveness to concanavalin A during experimental syphilis: evidence that glycosaminoglycans in the sera and tissues interfere ith active binding sites on the lectin and not with the lymphocytes.实验性梅毒期间淋巴细胞对刀豆球蛋白A反应性的重新评估：血清和组织中的糖胺聚糖干扰凝集素上的活性结合位点而非淋巴细胞的证据。
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7
The ability of peripheral blood mononuclear cells of rabbits infected with Treponema pallidum to produce IL-2.感染梅毒螺旋体的家兔外周血单个核细胞产生白细胞介素-2的能力。
FEMS Immunol Med Microbiol. 1993 Oct;7(3):257-64. doi: 10.1111/j.1574-695X.1993.tb00406.x.
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Effect of route of infection with Treponema pallidum. In vitro cellular response to treponemal antigens.梅毒螺旋体感染途径的影响。对梅毒螺旋体抗原的体外细胞反应。
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Effect of Treponema pallidum-infected testis supernatants on the cellular response of normal rabbit lymphocytes.梅毒螺旋体感染的睾丸上清液对正常兔淋巴细胞细胞反应的影响。
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Activation of macrophages by products of lymphocytes from normal and syphilitic rabbits.正常兔和梅毒兔淋巴细胞产物对巨噬细胞的激活作用。
Infect Immun. 1982 Jul;37(1):64-9. doi: 10.1128/iai.37.1.64-69.1982.

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Am J Pathol. 2010 Nov;177(5):2421-32. doi: 10.2353/ajpath.2010.100277. Epub 2010 Oct 1.
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Clin Microbiol Rev. 1995 Jan;8(1):1-21. doi: 10.1128/CMR.8.1.1.
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Transfer of resistance with syphilitic immune cells: lack of correlation with mitogenic activity.梅毒免疫细胞耐药性的转移：与促有丝分裂活性缺乏相关性。
Infect Immun. 1982 Jan;35(1):187-92. doi: 10.1128/iai.35.1.187-192.1982.
4
Reappraisal of lymphocyte responsiveness to concanavalin A during experimental syphilis: evidence that glycosaminoglycans in the sera and tissues interfere ith active binding sites on the lectin and not with the lymphocytes.实验性梅毒期间淋巴细胞对刀豆球蛋白A反应性的重新评估：血清和组织中的糖胺聚糖干扰凝集素上的活性结合位点而非淋巴细胞的证据。
Infect Immun. 1982 Feb;35(2):552-9. doi: 10.1128/iai.35.2.552-559.1982.
5
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Am J Pathol. 1980 Nov;101(2):387-414.
6
Cell-mediated immunity in Treponema pallidum infected rabbits: in vitro response of splenic and lymph node lymphocytes to mitogens and specific antigens.梅毒螺旋体感染兔的细胞介导免疫：脾和淋巴结淋巴细胞对有丝分裂原和特异性抗原的体外反应
Clin Exp Immunol. 1980 Jan;39(1):38-43.
7
Effect of Treponema pallidum-infected testis supernatants on the cellular response of normal rabbit lymphocytes.梅毒螺旋体感染的睾丸上清液对正常兔淋巴细胞细胞反应的影响。
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8
T lymphoid cells in primary syphilis. Quantitative studies.一期梅毒中的T淋巴细胞。定量研究。
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Uneven distribution of antitreponema antibody acitivity in differing immunoglobulin G fractions from patients with early syphilis.早期梅毒患者不同免疫球蛋白G组分中抗梅毒螺旋体抗体活性分布不均。
Infect Immun. 1980 Sep;29(3):837-41. doi: 10.1128/iai.29.3.837-841.1980.
10
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Infect Immun. 1982 Aug;37(2):568-78. doi: 10.1128/iai.37.2.568-578.1982.

本文引用的文献

1
Assessment of the "luotest" in late syphillis.“罗氏试验”在晚期梅毒中的评估。
Br J Vener Dis. 1966 Jun;42(2):119-21. doi: 10.1136/sti.42.2.119.
2
Runting syndrome in neonatal rabbits infected with Treponema pallidum.感染梅毒螺旋体的新生兔发育迟缓综合征
Clin Exp Immunol. 1967 May;2(3):311-20.
3
Relationship of in vitro lymphocyte transformation to delayed hypersensitivity in guinea pigs and man.豚鼠和人类体外淋巴细胞转化与迟发型超敏反应的关系。
Fed Proc. 1968 Jan-Feb;27(1):21-8.
4
In vitro lymphocyte response to Treponema refringens im human syphilis.人梅毒中对致密螺旋体的体外淋巴细胞反应。
Infect Immun. 1974 Apr;9(4):654-7. doi: 10.1128/iai.9.4.654-657.1974.
5
Why is the infectious stage of syphilis prolonged?梅毒的传染期为何会延长？
Br J Vener Dis. 1974 Feb;50(1):45-9. doi: 10.1136/sti.50.1.45.
6
Elicitation of selective T and B lymphocyte responses by cell surface binding ligands.通过细胞表面结合配体引发选择性T和B淋巴细胞反应。
Transplant Rev. 1972;11:87-130. doi: 10.1111/j.1600-065x.1972.tb00047.x.
7
DNA synthesis by cultured lymphocytes: a modified method for measuring 3H-thymidine incorporation.培养淋巴细胞的DNA合成：一种用于测量³H-胸腺嘧啶核苷掺入的改良方法。
Cell Immunol. 1973 Dec;9(3):435-44. doi: 10.1016/0008-8749(73)90058-0.
8
Detection of nonspecific resistance to Listeria monocytogenes in rabbits infected with Treponema pallidum.感染梅毒螺旋体的家兔对单核细胞增生李斯特菌非特异性抵抗力的检测
Infect Immun. 1974 Apr;9(4):658-62. doi: 10.1128/iai.9.4.658-662.1974.
9
Reduced lymphocyte transformation due to a plasma factor in patients with active syphilis.活动性梅毒患者血浆因子导致淋巴细胞转化降低。
Lancet. 1969 Aug 2;2(7614):246-7. doi: 10.1016/s0140-6736(69)90010-5.
10
Lymphocyte transformation in syphilis: an in vitro correlate of immune suppression in vivo?梅毒中的淋巴细胞转化：体内免疫抑制的体外相关因素？
Infect Immun. 1975 Jun;11(6):1261-4. doi: 10.1128/iai.11.6.1261-1264.1975.