Lee Jung Woo, Hur Jae, Yeo Kwang Yeoll, Yu Hee Joon, Kim Joung Soo
Department of Dermatology, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri, Korea.
Ann Dermatol. 2009 May;21(2):197-9. doi: 10.5021/ad.2009.21.2.197. Epub 2009 May 31.
Pigmented Bowen's disease is characterized by increased melanin pigment in the epidermis or papillary dermis, in addition to the typical findings of Bowen's disease. This disorder has been infrequently reported and it represents less than 2% of all cases of Bowen's disease. Thus far, there has been only 1 case of pigmented Bowen's disease on the umbilicus in the medical literature, and no such case has been reported in Korea. Pigmented Bowen's disease develops on sun-exposed areas of the face and neck, as well as sun-unexposed areas like the trunk, extremities, perianal area and umbilcus. A 36-year-old man presented with a 9-month history of solitary dark brown slithery or wavy plaque with a verrucous surface on the umbilicus, and the lesion measured 1 x 2 cm in size. The histopathologic findings showed hyperkeratosis, parakeratosis and atypical keratinocytes disorderly arranged throughout the epidermis. Increased melanin pigment was noted in the basal layer of the epidermis. From these findings, we diagnosed this lesion as pigmented Bowen's disease.
色素沉着性鲍恩病除具有鲍恩病的典型表现外,其特征还在于表皮或乳头真皮层中黑色素增加。这种疾病鲜有报道,在所有鲍恩病病例中占比不到2%。迄今为止,医学文献中仅1例脐部色素沉着性鲍恩病的报道,韩国尚无此类病例报告。色素沉着性鲍恩病可发生于面部和颈部等暴露于阳光的部位,也可发生于躯干、四肢、肛周区域和脐部等非暴露部位。一名36岁男性患者,脐部出现一个9个月病史的孤立性暗褐色、蜿蜒或波浪状斑块,表面呈疣状,病变大小为1×2厘米。组织病理学检查结果显示有角化过度、不全角化及非典型角质形成细胞在整个表皮中排列紊乱。在表皮基底层可见黑色素增加。根据这些发现,我们将该病变诊断为色素沉着性鲍恩病。