King Dana E, Mainous Arch G, Geesey Mark E, Woolson Robert F
Department of Family Medicine, Medical University of South Carolina, 295 Calhoun Street, PO Box 250192, Charleston, SC 29425, USA.
J Am Coll Nutr. 2005 Jun;24(3):166-71. doi: 10.1080/07315724.2005.10719461.
Current dietary guidelines recommend adequate intake of magnesium (310-420 mg daily) in order to maintain health and lower the risk of cardiovascular disease. Recent evidence from animal and clinical studies suggests that magnesium may be associated with inflammatory processes. The objective of this study was to determine whether dietary magnesium consumption is associated with C-reactive protein (CRP), a marker of inflammation, in a nationally representative sample.
Analysis of adult (> or =17 years) participants in a cross-sectional nationally representative survey (National Health and Nutrition Examination Survey 1999-2000 [NHANES]) who were not taking magnesium or magnesium-containing supplements. The primary outcome measure was high sensitivity CRP (elevated > or =3.0 mg/L).
Among US adults, 68% consumed less than the recommended daily allowance (RDA) of magnesium, and 19% consumed less than 50% of the RDA. After controlling for demographic and cardiovascular risk factors, adults who consumed <RDA of magnesium were 1.48-1.75 times more likely to have elevated CRP than adults who consumed > or =RDA (Odds Ratio [OR] for intake <50% RDA = 1.75, 95% Confidence Interval [CI] 1.08-2.87). Adults who were over age 40 with a BMI >25 and who consumed <50% RDA for magnesium were 2.24 times more likely to have elevated CRP (95% CI 1.13-4.46) than adults > or =RDA.
Most Americans consume magnesium at levels below the RDA. Individuals with intakes below the RDA are more likely to have elevated CRP, which may contribute to cardiovascular disease risk.
当前的饮食指南建议适量摄入镁（每日310 - 420毫克），以维持健康并降低心血管疾病风险。动物和临床研究的最新证据表明，镁可能与炎症过程有关。本研究的目的是在一个具有全国代表性的样本中，确定饮食中镁的摄入量是否与炎症标志物C反应蛋白（CRP）相关。
对参加全国代表性横断面调查（1999 - 2000年国家健康和营养检查调查[NHANES]）且未服用镁或含镁补充剂的成年人（≥17岁）进行分析。主要结局指标是高敏CRP（升高≥3.0毫克/升）。
在美国成年人中，68%的人镁摄入量低于推荐每日摄入量（RDA），19%的人摄入量低于RDA 的50%。在控制了人口统计学和心血管危险因素后，如果把那些摄入镁≥RDA 的成年人作为参照，摄入镁＜RDA 的成年人CRP升高可能性是其1.48 - 1.75倍（摄入＜50%RDA 的优势比[OR]=1.75，95%置信区间[CI]=1.08 - 2.87）。40岁以上、BMI＞25且镁摄入量＜50%RDA 的成年人CRP升高可能性比摄入镁≥RDA 的成年人高2.24倍（95%CI=1.13 - 4.46）。
大多数美国人镁的摄入量低于RDA。摄入量低于RDA 的个体更有可能出现CRP升高，这可能会增加心血管疾病风险。
