Cliffe Laura J, Humphreys Neil E, Lane Thomas E, Potten Chris S, Booth Cath, Grencis Richard K
Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK.
Science. 2005 Jun 3;308(5727):1463-5. doi: 10.1126/science.1108661.
The functional integrity of the intestinal epithelial barrier forms a major defense against invading pathogens, including gastrointestinal-dwelling nematodes, which are ubiquitous in their distribution worldwide. Here, we show that an increase in the rate of epithelial cell turnover in the large intestine acts like an "epithelial escalator" to expel Trichuris and that the rate of epithelial cell movement is under immune control by the cytokine interleukin-13 and the chemokine CXCL10. This host protective mechanism against intestinal pathogens has implications for our wider understanding of the multifunctional role played by intestinal epithelium in mucosal defense.
肠道上皮屏障的功能完整性构成了抵御入侵病原体的主要防线，这些病原体包括在全球广泛分布的寄生于胃肠道的线虫。在此，我们表明，大肠上皮细胞更新率的增加起到了“上皮电梯”的作用，可排出鞭虫，且上皮细胞移动速率受细胞因子白细胞介素-13和趋化因子CXCL10的免疫控制。这种针对肠道病原体的宿主保护机制有助于我们更全面地理解肠道上皮在黏膜防御中所起的多功能作用。
