Walsh L J, Cleveland D B, Cumming C G
Department of Dermatology, University of Pennsylvania, Philadelphia.
J Oral Pathol Med. 1992 Jan;21(1):28-32. doi: 10.1111/j.1600-0714.1992.tb00965.x.
Langerhans cells (LC) serve as antigen presenting cells and provide immune surveillance within epithelia. Since depression of LC number and/or function may allow tolerance to antigens, we evaluated LC in median rhomboid glossitis (MRG), a condition linked to persistent candidal infection of lingual mucosa. Material included a total of 36 cases of MRG (7 of which did not show PAS + fungi) and 6 controls. LC were identified by their expression of S-100 and HLA-DR antigens and quantified using image analysis. Equal numbers of LC were identified using S-100 + and HLA-DR + markers. The density of LC (cells/mm of basement membrane, mean +/- SD) in both PAS + MRG (2.6 +/- 1.3) and PAS-MRG (3.0 +/- 1.7) was markedly depressed compared with controls (17.2 +/- 6.4), (P less than 0.001). These findings indicate that the LC network is perturbed in MRG, and are consistent with the view that of localized defect in immune surveillance may contribute to persistent fungal infection of the oral mucosa.
朗格汉斯细胞（LC）作为抗原呈递细胞，在上皮内提供免疫监视。由于LC数量和/或功能的降低可能会导致对抗原的耐受性，我们评估了正中菱形舌炎（MRG）中的LC，这是一种与舌黏膜持续性念珠菌感染相关的病症。材料包括总共36例MRG（其中7例未显示PAS +真菌）和6例对照。通过其S-100和HLA-DR抗原的表达鉴定LC，并使用图像分析进行定量。使用S-100 +和HLA-DR +标记鉴定出相等数量的LC。与对照组（17.2 +/- 6.4）相比，PAS + MRG（2.6 +/- 1.3）和PAS-MRG（3.0 +/- 1.7）中LC的密度（每毫米基底膜的细胞数，平均值+/-标准差）均明显降低（P小于0.001）。这些发现表明，MRG中的LC网络受到干扰，并且与以下观点一致，即免疫监视中的局部缺陷可能导致口腔黏膜的持续性真菌感染。
