Arendorf T M, Walker D M
Int J Oral Surg. 1984 Oct;13(5):411-5. doi: 10.1016/s0300-9785(84)80067-8.
The importance of tobacco smoking and denture wearing in the aetiology of median rhomboid glossitis (MRG) has been evaluated in 39 patients. Significantly more of the MRG patients (85%) smoked tobacco compared with the corresponding proportion (41%) of the 39 healthy age-and sex-matched control subjects. Their tobacco consumption was also heavier. A significantly greater proportion of the MRG patients wore their dentures continuously compared with the controls. The number of MRG patients who were both tobacco smokers and denture wearers was significantly increased above that of the control group, as was the number who both smoked and wore dentures continuously. Only 1 patient neither smoked nor wore dentures and she was taking an antidepressant (imipramine hydrochloride) with a reported association with oral candidosis. It is suggested that these local factors may play a part in the development of MRG by favouring the local proliferation of Candida albicans on the dorsum of the tongue. Although conservative or surgical treatment may provide relief, management should also include attention to possible predisposing local factors.
对39例正中菱形舌炎（MRG）患者评估了吸烟和佩戴假牙在其病因学中的重要性。与39名年龄和性别匹配的健康对照受试者的相应比例（41%）相比，MRG患者中吸烟的比例（85%）显著更高。他们的烟草消费量也更大。与对照组相比，MRG患者中持续佩戴假牙的比例显著更高。既是吸烟者又是假牙佩戴者的MRG患者数量比对照组显著增加，既吸烟又持续佩戴假牙的患者数量也是如此。只有1例患者既不吸烟也不佩戴假牙，她正在服用一种据报道与口腔念珠菌病有关的抗抑郁药（盐酸丙咪嗪）。提示这些局部因素可能通过促进白色念珠菌在舌背局部增殖而在MRG的发生中起作用。虽然保守或手术治疗可能会缓解症状，但治疗还应包括关注可能的易感局部因素。
