Kolovou G D, Anagnostopoulou K K, Cokkinos D V
1st Cardiology Department, Onassis Cardiac Surgery Centre, Athens, Greece.
Postgrad Med J. 2005 Jun;81(956):358-66. doi: 10.1136/pgmj.2004.025601.
The insulin resistance/metabolic syndrome is characterised by the variable coexistence of hyperinsulinaemia, obesity, dyslipidaemia, and hypertension. The pathogenesis of the syndrome has multiple origins, but obesity and sedentary lifestyle coupled with diet and still largely unknown genetic factors clearly interact to produce the syndrome. Dyslipidaemia, the hallmark of the metabolic syndrome, includes increased flux of free fatty acids, raised triglycerides, apolipoprotein B, and small dense low density lipoprotein, and decreased high density lipoprotein cholesterol. The widely prevalent nature of the metabolic syndrome emphasises the importance of its diagnosis and treatment. This review analyses the clinical and dynamic features of this syndrome in the aspect of dyslipidaemia and its management.
胰岛素抵抗/代谢综合征的特征是高胰岛素血症、肥胖、血脂异常和高血压等多种症状并存。该综合征的发病机制有多种根源，但肥胖、久坐不动的生活方式、饮食以及很大程度上仍不明确的遗传因素显然相互作用，导致了该综合征的发生。血脂异常是代谢综合征的标志，包括游离脂肪酸通量增加、甘油三酯升高、载脂蛋白B和小而密的低密度脂蛋白增加，以及高密度脂蛋白胆固醇降低。代谢综合征的广泛流行凸显了其诊断和治疗的重要性。本综述从血脂异常及其管理方面分析了该综合征的临床和动态特征。
