Touriño Sonia, Selga Ariadna, Jiménez Aurora, Juliá Lluís, Lozano Carles, Lizárraga Daneida, Cascante Marta, Torres Josep Lluís
Institute for Chemical and Environmental Research (IIQAB-CSIC), Jordi Girona 18-26, 08034 Barcelona, Spain.
J Agric Food Chem. 2005 Jun 15;53(12):4728-35. doi: 10.1021/jf050262q.
Pine (Pinus pinaster) bark is a rich source of procyanidin oligomers. From a total polyphenolic extract, we have generated fractions of different procyanidin composition. The mixtures, devoid of gallate esters, were active as free radical scavengers against ABTS(*+), DPPH, and HNTTM. Pine bark fractions were tested for antioxidant activity in solution (hydrogen donation and electron transfer) and emulsion (inhibition of lipid peroxidation) and compared with their galloylated counterparts from grape origin. While galloylation clearly influenced the free radical scavenging efficiency in solution, it did not seem to play a determinant role in protection against lipid peroxidation in emulsion. The fractions were very mild inhibitors of cell proliferation. Because gallate esters appear to interfere with crucial cell functions, gallate free pine procyanidins may be the innocuous chemopreventative agents of choice for many applications in food and skin protection.
松树（海岸松）树皮是原花青素低聚物的丰富来源。从总多酚提取物中，我们得到了不同原花青素组成的馏分。这些不含没食子酸酯的混合物作为自由基清除剂对ABTS（*+）、DPPH和HNTTM具有活性。对松树皮馏分在溶液中（氢供体和电子转移）和乳液中（抑制脂质过氧化）的抗氧化活性进行了测试，并与来自葡萄的相应没食子酰化馏分进行了比较。虽然没食子酰化明显影响了溶液中的自由基清除效率，但它似乎在乳液中防止脂质过氧化方面不起决定性作用。这些馏分是非常温和的细胞增殖抑制剂。由于没食子酸酯似乎会干扰关键的细胞功能，不含没食子酸的松树原花青素可能是食品和皮肤保护中许多应用的无害化学预防剂的首选。
