Yih Wei-Yung, Kratochvil F James, Stewart Jeffery C B
Department of Pathology and Radiology, Oregon Health and Science University School of Dentistry, Portland 97239-3098, USA.
J Oral Maxillofac Surg. 2005 Jun;63(6):805-10. doi: 10.1016/j.joms.2005.02.021.
Minor salivary gland tumors (MSGTs) constitute a heterogeneous group of neoplasms with great histomorphologic variation. This study reviews a large series of benign and malignant salivary gland tumors of the oral region and determines the incidence and the correlation of the histopathologic features with the clinical characteristics.
Two hundred thirteen cases of MSGT were retrospectively studied. Hematoxylin-eosin-stained slides were examined in all cases. Special stains and immunohistochemical stains were used in selected cases. Clinical characteristics of the neoplasms were also noted.
One hundred nineteen tumors were benign (56%), and 94 tumors were malignant (44%). Pleomorphic adenoma was the most common benign tumor (93 of 119). Canalicular adenoma was the second most common benign MSGT in our series (25 of 119). Of the 94 malignant MSGTs, mucoepidermoid carcinoma (MEC) (45 of 94), adenoid cystic carcinoma (22 of 94), and polymorphous low-grade adenocarcinoma (18 of 94) were the most common. Most MECs (34 of 45) were low-grade lesions. Of 5 central MECs, 3 cases occurred in the maxilla and 2 cases arose in the mandible.
Benign intraoral MSGTs are slightly more common than malignant MSGTs. Pleomorphic adenoma is the most common MSGT, and MEC is the most common malignant variety. The palate is the most common site for minor gland neoplasms. Benign labial salivary gland neoplasms are more common in the upper lip, and malignant labial tumors are more common in the lower lip.
小涎腺肿瘤（MSGTs）是一组异质性肿瘤，具有很大的组织形态学差异。本研究回顾了一大系列口腔区域的良性和恶性涎腺肿瘤，并确定其发病率以及组织病理学特征与临床特征之间的相关性。
对213例小涎腺肿瘤进行回顾性研究。所有病例均检查苏木精-伊红染色切片。部分病例使用特殊染色和免疫组化染色。同时记录肿瘤的临床特征。
119例肿瘤为良性（56%），94例为恶性（44%）。多形性腺瘤是最常见的良性肿瘤（119例中的93例）。小管状腺瘤是本系列中第二常见的良性小涎腺肿瘤（119例中的25例）。在94例恶性小涎腺肿瘤中，黏液表皮样癌（MEC）（94例中的45例）、腺样囊性癌（94例中的22例）和多形性低度腺癌（94例中的18例）最为常见。大多数黏液表皮样癌（45例中的34例）为低级别病变。5例中央型黏液表皮样癌中，3例发生在上颌骨，2例发生在下颌骨。
口腔内良性小涎腺肿瘤比恶性小涎腺肿瘤略常见。多形性腺瘤是最常见的小涎腺肿瘤，黏液表皮样癌是最常见的恶性类型。腭部是小涎腺肿瘤最常见的部位。唇部良性涎腺肿瘤在上唇更常见，唇部恶性肿瘤在下唇更常见。
