Redman Christopher W, Sargent Ian L
Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK.
Science. 2005 Jun 10;308(5728):1592-4. doi: 10.1126/science.1111726.
Preeclampsia is a relatively common pregnancy disorder that originates in the placenta and causes variable maternal and fetal problems. In the worst cases, it may threaten the survival of both mother and baby. We summarize recent work on the causes of preeclampsia, which reveals a new mode of maternal immune recognition of the fetus, relevant to the condition. The circulating factors derived from the placenta, which contributes to the clinical syndrome, are now better understood. This brief review on preeclampsia does not cover all aspects of this intriguing condition but focuses on some new and interesting findings.
子痫前期是一种相对常见的妊娠疾病，起源于胎盘，会导致各种母婴问题。在最严重的情况下，它可能威胁母婴的生命。我们总结了近期关于子痫前期病因的研究工作，这些研究揭示了一种与该病症相关的母体对胎儿免疫识别的新模式。目前，对导致临床综合征的胎盘衍生循环因子有了更好的理解。这篇关于子痫前期的简要综述并未涵盖这一复杂病症的所有方面，而是聚焦于一些新的有趣发现。
