Williams Alun G, Day Stephen H, Folland Jonathan P, Gohlke Peter, Dhamrait Sukhbir, Montgomery Hugh E
Institute for Biophysical and Clinical Research into Human Movement, Manchester Metropolitan University, UK.
Med Sci Sports Exerc. 2005 Jun;37(6):944-8.
The D-variant of the angiotensin-1 converting enzyme (ACE) gene is associated with higher circulating and tissue ACE activity. Some studies have suggested a similar association of genotype with muscle strength or the gain in strength in response to training. This study has assessed the relationship between circulating ACE activity, strength, and the response to training.
Eighty-one untrained men were tested for quadriceps muscle strength, and 44 of these performed an 8-wk program of dynamic strength training of the quadriceps muscle group. Venous blood was obtained for assessment of circulating ACE activity before and after the training program. ACE genotype was also determined.
At baseline, circulating ACE activity was significantly correlated with isometric (r = 0.25-0.29, P < 0.02) and isokinetic (r = 0.38, P < 0.0005) quadriceps muscle strength. ACE genotype also seemed to be related to pretraining muscle strength. However, circulating ACE activity showed no significant association with the 9-14% mean increases of muscle strength in response to the training intervention. ACE genotype also showed no association with the training-induced change in muscle strength. Circulating ACE activity did not change significantly after the training program.
The data support a role for ACE in the regulation of human skeletal muscle strength, but do not confirm a role in altering the response to short-term training.
血管紧张素转换酶（ACE）基因的D型与循环及组织中较高的ACE活性相关。一些研究表明该基因型与肌肉力量或训练后力量增加存在类似关联。本研究评估了循环ACE活性、力量以及训练反应之间的关系。
对81名未经训练的男性进行股四头肌力量测试，其中44人进行了为期8周的股四头肌动态力量训练计划。在训练计划前后采集静脉血以评估循环ACE活性。同时也确定了ACE基因型。
在基线时，循环ACE活性与股四头肌等长力量（r = 0.25 - 0.29，P < 0.02）和等速力量（r = 0.38，P < 0.0005）显著相关。ACE基因型似乎也与训练前的肌肉力量有关。然而，循环ACE活性与训练干预后肌肉力量平均增加9 - 14%无显著关联。ACE基因型与训练引起的肌肉力量变化也无关联。训练计划后循环ACE活性无显著变化。
数据支持ACE在调节人类骨骼肌力量中起作用，但未证实其在改变短期训练反应方面的作用。
