Jalal Hamid, Bibby David F, Tang Julian W, Bennett Julie, Kyriakou Chara, Peggs Karl, Cubitt David, Brink Nicola S, Ward Kate N, Tedder Richard S
Clinical Microbiology & Public Health Laboratory, Addenbrooke's Hospital, Cambridge, Hills Road, Cambridge CB2 2QW, United Kingdom.
J Clin Microbiol. 2005 Jun;43(6):2575-80. doi: 10.1128/JCM.43.6.2575-2580.2005.
Numerous outbreaks of adenovirus infection from different types of health care settings, except a hematology unit, have been reported. This is the first report describing an outbreak of adenovirus infection causing diarrhea among adult hematopoietic stem cell transplant recipients. Six of 21 patients from the outbreak cohort were affected with diarrhea. Electron microscopy, cell culture, and direct DNA sequencing of amplicons generated from stool and blood samples were used to investigate this outbreak. Electron microscopy and cell culture detected adenovirus in stools from symptomatic patients. DNA sequencing of amplicons generated from stool samples confirmed nosocomial transmission of infection from a single index case. The outbreak strain was also detected in plasma of four of these patients, suggesting systemic infection. The outbreak strain was identified as type 12. Standard infection control measures were effective to control this outbreak.
除血液科外，已报告了来自不同类型医疗机构的多起腺病毒感染暴发事件。这是第一份描述成年造血干细胞移植受者中腺病毒感染导致腹泻暴发的报告。暴发队列中的21名患者中有6名出现腹泻。通过电子显微镜、细胞培养以及对粪便和血液样本扩增产物进行直接DNA测序来调查此次暴发。电子显微镜和细胞培养在有症状患者的粪便中检测到腺病毒。对粪便样本扩增产物进行的DNA测序证实感染是由单一索引病例发生医院内传播所致。在其中4名患者的血浆中也检测到了暴发菌株，提示存在全身感染。暴发菌株被鉴定为12型。标准的感染控制措施有效控制了此次暴发。
