Oner Ayse, Coskun Mesut, Evereklioglu Cem, Dogan Hakki
Department of Ophthalmology, Erciyes University Medical Faculty, Kayseri, Turkey.
Doc Ophthalmol. 2004 Nov;109(3):223-7. doi: 10.1007/s10633-004-7098-y.
To evaluate the effectiveness and clinical significance of pattern visual evoked potential (P-VEP) parameters on visual acuity in amblyopic patients under occlusion therapy.
A total of 34 consecutive children with anisometropic amblyopia were included in this study. All patients underwent a full initial ophthalmologic and orthoptic evaluation. P-VEP test was performed in all cases and binocular vision was tested and recorded with Worth's four-dot test and Bagolini striated glasses at each visit. Part-time occlusion therapy was performed by using adhesive patches.
The mean (+/- SEM) cycloplegic refractive error was + 5.6 +/- 0.6 diopters (D) in the amblyopic eyes and + 1.8 +/- 0.2 D in the normal eye. The mean levels of best-corrected visual acuity were statistically differed between each measurement for occlusion therapy (for each, p < 0.05). The ratio of the patients with binocular vision increased after 6 months occlusion therapy and the difference was statistically significant (p < 0.05). In addition, P100 amplitude improved at each visit and the difference was significant when compared with baseline values (for each, p < 0.05).
P100 amplitude of the P-VEP test parallels the improvement in subjective visual acuity in amblyopic eyes under occlusion therapy. Therefore, this test may be useful in monitoring the visual acuity in the preverbal or non-verbal patched patients.
评估在遮盖治疗下，图形视觉诱发电位（P-VEP）参数对弱视患者视力的有效性和临床意义。
本研究纳入了34例连续性屈光参差性弱视儿童。所有患者均接受了全面的初始眼科和视光学评估。所有病例均进行了P-VEP测试，每次就诊时使用Worth四点测试和Bagolini线状镜测试并记录双眼视觉。采用粘贴眼罩进行部分时间遮盖治疗。
弱视眼的平均（±标准误）睫状肌麻痹验光度数为+5.6±0.6屈光度（D），正常眼为+1.8±0.2D。遮盖治疗的每次测量之间，最佳矫正视力的平均水平在统计学上存在差异（每次，p<0.05）。遮盖治疗6个月后，双眼视觉患者的比例增加，差异具有统计学意义（p<0.05）。此外，每次就诊时P100波幅均有所改善，与基线值相比差异显著（每次，p<0.05）。
在遮盖治疗下，P-VEP测试的P100波幅与弱视眼主观视力的改善情况平行。因此，该测试可能有助于监测接受遮盖治疗的婴幼儿或无法言语表达的患者的视力。
