Xiao Manyi, Wei Xin, Li Yunping, Xiong Wei, Xu Shuxian
Department of Ophthalmology, Second Xiangya Hospital, Central South University, Changsha 410011,China.
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2013 Jul;38(7):704-8. doi: 10.3969/j.issn.1672-7347.2013.07.010.
To evaluate the clinical significance of pattern visual evoked potential (P-VEP) parameters on amblyopic patients with normal-vision after pleoptic therapy.
We investigated 60 amblyopic children (8-12 years old) who gained normal-vision after pleoptic therapy. These patients were assigned to a unilateral amblyopia group (40 patients) and a bilateral amblyopia group (20 patients). Another 20 healthy children served as a control group. All patients underwent a full initial ophthalmologic and orthoptic evaluation. P-VEP test was performed in all. Amplitude and latencies were analyzed and compared among groups. The latencies of P100 waves in the amblyopic eyes were used to generate a multiple linear regression formula from sex, first treatment age, baseline visual acuity, and cycloplegic refraction.
There was no significant difference in the mean levels of best-corrected visual acuity among groups (P>0.05). A significant prolongation of the latency and a decrease of amplitude of P100 waves were observed in the unilateral amblyopia group and the bilateral amblyopia group compared with the healthy control group (P<0.05). Amplitude and latencies of the fellow eyes in the unilateral amblyopia group were abnormal compared with the healthy control group (P<0.05). Multiple linear regression analysis revealed that the latencies of P100 waves were significantly correlated with the first treatment age, baseline visual acuity, and cycloplegic refraction (R(2)= 0.52, P<0.05).
Deficits exist in the fellow eyes and in normal-vision eyes after pleoptic therapy. The delayed P100 latency is affected by the first treatment age, baseline visual acuity, and cycloplegic refraction. Traditional amblyopic therapy may be not enough for vision function recovery.
评估图形视觉诱发电位（P-VEP）参数对经弱视综合疗法治疗后视力恢复正常的弱视患者的临床意义。
我们调查了60例经弱视综合疗法治疗后视力恢复正常的弱视儿童（8至12岁）。这些患者被分为单眼弱视组（40例）和双眼弱视组（20例）。另外20名健康儿童作为对照组。所有患者均接受了全面的初始眼科和视光学评估。所有人都进行了P-VEP测试。分析并比较了各组之间的振幅和潜伏期。使用弱视眼P100波的潜伏期，根据性别、首次治疗年龄、基线视力和睫状肌麻痹验光结果生成多元线性回归公式。
各组之间最佳矫正视力的平均水平无显著差异（P>0.05）。与健康对照组相比，单眼弱视组和双眼弱视组均观察到P100波潜伏期显著延长和振幅降低（P<0.05）。与健康对照组相比，单眼弱视组对侧眼的振幅和潜伏期异常（P<0.05）。多元线性回归分析显示，P100波的潜伏期与首次治疗年龄、基线视力和睫状肌麻痹验光结果显著相关（R(2)= 0.52，P<0.05）。
弱视综合疗法治疗后，对侧眼和视力恢复正常的眼睛存在功能缺陷。P100潜伏期延迟受首次治疗年龄、基线视力和睫状肌麻痹验光结果影响。传统的弱视治疗可能不足以恢复视功能。
