Yamamoto Hiroki, Watanabe Keita, Momma Shota, Tatsuo Soichiro, Matsuzaka Masashi, Tamada Yoshinori, Mikami Tatsuya, Nakaji Shigeyuki, Kakeda Shingo
Department of Radiology, Graduate School of Medicine, Hirosaki University, Hirosaki, Japan.
Department of Radiology, Kyoto Prefectural University of Medicine, 465 Kajiimachi, Jokyo-ku, Kyoto, Kyoto-shi, Kyoto-fu, Japan.
Neuroradiology. 2025 Mar;67(3):575-581. doi: 10.1007/s00234-024-03512-x. Epub 2024 Nov 26.
Although previous studies have reported that hemoglobin levels can affect the brain, very few have focused on the association between hemoglobin levels and brain volume. We aimed to identify the influence of hemoglobin levels on brain volume measured using magnetic resonance imaging (MRI) in a large elderly population.
This cross-sectional study included 2153 participants (median age, 69 years; 60.2% female) who underwent 3T brain MRI. Multiple regression analyses were performed after adjusting for potential confounders. In the subgroup analyses, participants were divided into four groups according to sex and age threshold (lower age group [65-74] and higher age group [≥ 75]).
After adjusting for potential confounders, total white matter volume reduction was found to be associated with decreased hemoglobin levels (females: standardized β = 0.059, [95% confidence interval (CI): 0.0032, 0.11], P = 0.038, males: standardized β = 0.069 [95% CI: -0.00023, 0.14], P = 0.051). This relationship was notable in younger age groups of both sexes. After adjustment, the total gray matter and hippocampal volumes were not significantly associated with hemoglobin levels.
Low hemoglobin levels may have deleterious effects on white matter volume, which diminishes with age.
尽管先前的研究报告称血红蛋白水平会影响大脑，但很少有研究关注血红蛋白水平与脑容量之间的关联。我们旨在确定在一大群老年人群中，血红蛋白水平对使用磁共振成像（MRI）测量的脑容量的影响。
这项横断面研究纳入了2153名参与者（年龄中位数为69岁；女性占60.2%），他们接受了3T脑部MRI检查。在对潜在混杂因素进行调整后进行了多元回归分析。在亚组分析中，参与者根据性别和年龄阈值分为四组（较低年龄组[65 - 74岁]和较高年龄组[≥75岁]）。
在对潜在混杂因素进行调整后，发现总白质体积减少与血红蛋白水平降低有关（女性：标准化β = 0.059，[95%置信区间（CI）：0.0032，0.11]，P = 0.038；男性：标准化β = 0.069 [95% CI： - 0.00023，0.14]，P = 0.051）。这种关系在男女较年轻的年龄组中都很明显。调整后，总灰质体积和海马体体积与血红蛋白水平无显著关联。
低血红蛋白水平可能对白质体积有有害影响，且这种影响会随着年龄增长而减弱。
