Gonzalez Armando E, Gauci Charles G, Barber Dylan, Gilman Robert H, Tsang Victor C W, Garcia Hector H, Verastegui Manuela, Lightowlers Marshall W
School of Veterinary Medicine, Universidad Nacional Mayor de San Marcos, Lima, Peru.
Am J Trop Med Hyg. 2005 Jun;72(6):837-9.
Taenia solium taeniasis/cysticercosis is a zoonotic disease complex in which the pig is an obligate intermediate host. The infection is widespread, particularly in the developing world, and neurocysticercosis is a major cause of human neurologic disease where the parasite is endemic. Despite easy availability, effective anti-parasitic drugs have not been deployed effectively to control disease transmission. We have investigated a vaccine strategy to prevent parasite infection of the pig intermediate host. Such a strategy would interrupt the parasite's life cycle and eliminate the source of infection for humans. Two recombinant antigens selected from the parasite oncosphere life cycle stage were tested in vaccination trials in pigs that were challenged orally with Taenia solium eggs. Both antigens were highly effective in protecting the pigs against infection with the parasite (98.6% and 99.9% protection, respectively). No viable cysts were found in eight pigs vaccinated with one of the antigens. A recombinant subunit vaccine based on oncosphere antigens has the potential to improve the available control measures for T. solium and thereby reduce or eliminate neurocysticercosis.
猪带绦虫病/囊尾蚴病是一种人畜共患疾病复合体，其中猪是必需的中间宿主。这种感染分布广泛，尤其是在发展中世界，而神经囊尾蚴病是寄生虫流行地区人类神经系统疾病的主要病因。尽管有易于获得的有效抗寄生虫药物，但尚未有效用于控制疾病传播。我们研究了一种预防猪中间宿主寄生虫感染的疫苗策略。这样的策略将中断寄生虫的生命周期并消除人类感染源。从寄生虫六钩蚴生命周期阶段选择的两种重组抗原在猪的疫苗接种试验中进行了测试，这些猪经口感染猪带绦虫虫卵。两种抗原在保护猪免受寄生虫感染方面都非常有效（分别为98.6%和99.9%的保护率）。在接种其中一种抗原的八头猪中未发现活的囊肿。基于六钩蚴抗原的重组亚单位疫苗有可能改善现有的猪带绦虫控制措施，从而减少或消除神经囊尾蚴病。
