Department of Veterinary Science, The University of Melbourne, 250 Princes Highway, Werribee, Victoria 3030, Australia.
Parasitology. 2013 Nov;140(13):1566-77. doi: 10.1017/S0031182013001005. Epub 2013 Aug 15.
Neurocysticercosis continues to be a major health burden on humans living in many regions of the world, despite the availability of highly effective taeniacides and identification of the cause, Taenia solium, as being potentially eradicable. Several T. solium control trials have been undertaken, generally achieving limited success and none that has been fully documented has achieved what was demonstrated to be a sustainable level of disease control. Pigs act as intermediate hosts for T. solium and two new control tools have become available for application in pigs - single-dose oxfendazole treatment of porcine cysticercosis and the TSOL18 vaccine. Three potential intervention scenarios for pigs are compared for control of cysticercosis, using either oxfendazole or vaccination. A control scenario involving vaccination plus oxfendazole treatment delivered at 4 monthly intervals was predicted to achieve the best outcome, with no pigs slaughtered at 12 months of age having viable T. solium cysticerci. Now that new control tools are available, there are opportunities to concentrate research attention on evaluation of novel control scenarios leading to the implementation of effective and sustainable control programmes and a reduction in the global burden of neurocysticercosis.
尽管有高效的抗绦虫药物和可以被根除的绦虫病病因（猪带绦虫），神经囊尾蚴病仍然是世界上许多地区人类的主要健康负担。已经进行了几项猪带绦虫病控制试验，但通常只取得了有限的成功，而且没有一项得到充分记录的试验达到了可持续控制疾病的水平。猪是猪带绦虫的中间宿主，两种新的控制工具已可用于猪 - 吡喹酮单次剂量治疗猪囊尾蚴病和 TSOL18 疫苗。为了控制囊尾蚴病，使用吡喹酮或疫苗，比较了三种针对猪的潜在干预方案。预测每隔 4 个月进行一次疫苗接种加吡喹酮治疗的控制方案将取得最佳效果，在 12 个月大时，没有一头可食用的猪带有存活的猪带绦虫囊尾蚴。现在有了新的控制工具，就有机会集中研究注意力，评估新的控制方案，以实施有效的和可持续的控制计划，并减少全球神经囊尾蚴病的负担。
