Junquera Luis, Torre Aintza, Vicente Juan C, García-Consuegra Luis, Fresno Manuel F
Department of Oral and Maxillofacial Surgery, University of Oviedo, Central Hospital of Asturias, Oviedo, Spain.
Ann Otol Rhinol Laryngol. 2005 May;114(5):376-80. doi: 10.1177/000348940511400507.
Merkel cell carcinoma (MCC) is a very aggressive primary cutaneous neoplasm most often occurring on the head and neck of the elderly. Spontaneous regression of MCC was first described in 1986. A 79-year-old woman with MCC on the right cheek underwent spontaneous regression of the malignancy, documented by photographic follow-up, computed tomography, and histologic studies. A review of the literature is presented. Complete clinical and histologic regression of MCC was observed in the present case. Although the literature documents 11 similar cases, only 6 can be regarded as complete spontaneous regressions following exclusive performance of a biopsy (primary complete spontaneous regression). Primary complete spontaneous regression of MCC is infrequent, and most case reports describe this phenomenon in women with MCC on the cheek. The reasons underlying regression are unknown.
默克尔细胞癌（MCC）是一种极具侵袭性的原发性皮肤肿瘤，最常发生于老年人的头颈部。MCC的自发消退最早于1986年被描述。一名79岁右脸颊患有MCC的女性，其恶性肿瘤出现了自发消退，通过摄影随访、计算机断层扫描和组织学研究得以记录。现呈现文献综述。在本病例中观察到MCC的临床和组织学完全消退。尽管文献记载了11例类似病例，但只有6例可被视为仅在进行活检后出现的完全自发消退（原发性完全自发消退）。MCC的原发性完全自发消退并不常见，大多数病例报告描述的是脸颊患有MCC的女性出现这种现象。消退的潜在原因尚不清楚。
